A Toxicological Evaluation of Mango Leaf Extract (Mangifera indica) Containing 60% Mangiferin

Table 7

Summary of macroscopic observations.

Organs	Dose group mg/kg bw/day	Control	500	1000	2000
	Observations	n=10	n=10	n=10	n=10
Males
	No macroscopic findings	10/10	7/10	8/10	9/10
Kidneys	Pyelectasia	0/10	2/10	2/10	1/10
Epididymides	Yellow-green formation	0/10	1/10	0/10	0/10
Diaphragm	Hernia diaphragmatic	0/10	0/10	0/10	1/10
Females
	No macroscopic findings	7/10	5/10	3/10	4/10
Thymus	Light orange colored	0/10	1/10	0/10	0/10
Kidneys	Pyelectasia	1/10	0/10	1/10	2/10
Spleen	Adhesion to the intestines	0/10	0/10	0/10	1/10
	Formation	0/10	0/10	0/10	1/10
Uterus	Hydrometra	3/10	5/10	6/10	3/10
Tail	Damage at the end	0/10	0/10	1/10	0/10
Skin	Alopecia	0/10	0/10	1/10	0/10
Diaphragm	Hernia diaphragmatic	0/10	0/10	0/10	1/10

Data represent the number of animals with observations / number of animals examined.