A Toxicological Evaluation of Mango Leaf Extract (Mangifera indica) Containing 60% Mangiferin
Table 8
Summary of relevant findings for absolute organ weights in male and female rats, 90-day study.
Group
Absolute organ weight (g)
Males
Females
mg/kg bw/day
Body
Heart
Testes
Epididymides
Body
Heart
n=10
weight
weight
Control
Mean
442.5
1.10
3.57
1.46
241.6
0.68
SD
28.94
0.09
0.30
0.13
12.89
0.04
500
Mean
456.2
1.13
3.81
1.64
245.5
0.74
SD
54.93
0.17
0.21
0.23
18.43
0.05
SS
1000
Mean
422.3
0.99
3.51
1.46
242.3
0.72
SD
36.69
0.07
0.25
0.14
15.50
0.05
SS
2000
Mean
442.3
1.07
3.93
1.51
238.5
0.71
SD
61.46
0.15
0.28
0.15
17.28
0.06
SS
test for significance
NS
U
DN
DN
NS
DN
historical control range
344-488
0.97-1.50
2.58-4.20
1.39-1.93
206-285
0.66-0.96
DN: Duncan’s multiple range test; n: number of animals/group; NS: not significant; SD: standard deviation; SS: statistical significance; U: Mann-Whitney U-test versus control. = p < 0.05 = p < 0.01.