A Toxicological Evaluation of Mango Leaf Extract (Mangifera indica) Containing 60% Mangiferin

Table 8

Summary of relevant findings for absolute organ weights in male and female rats, 90-day study.

Group		Absolute organ weight (g)
		Males				Females
mg/kg bw/day		Body	Heart	Testes	Epididymides	Body	Heart
n=10		weight				weight
Control	Mean	442.5	1.10	3.57	1.46	241.6	0.68
	SD	28.94	0.09	0.30	0.13	12.89	0.04
500	Mean	456.2	1.13	3.81	1.64	245.5	0.74
	SD	54.93	0.17	0.21	0.23	18.43	0.05
	SS
1000	Mean	422.3	0.99	3.51	1.46	242.3	0.72
	SD	36.69	0.07	0.25	0.14	15.50	0.05
	SS
2000	Mean	442.3	1.07	3.93	1.51	238.5	0.71
	SD	61.46	0.15	0.28	0.15	17.28	0.06
	SS
test for significance		NS	U	DN	DN	NS	DN
historical control range		344-488	0.97-1.50	2.58-4.20	1.39-1.93	206-285	0.66-0.96

DN: Duncan’s multiple range test; n: number of animals/group; NS: not significant; SD: standard deviation; SS: statistical significance; U: Mann-Whitney U-test versus control.
= p < 0.05
= p < 0.01.