Journal of Toxicology / 2019 / Article / Tab 8

Research Article

A Toxicological Evaluation of Mango Leaf Extract (Mangifera indica) Containing 60% Mangiferin

Table 8

Summary of relevant findings for absolute organ weights in male and female rats, 90-day study.

GroupAbsolute organ weight (g)
MalesFemales
mg/kg bw/dayBodyHeartTestesEpididymidesBodyHeart
n=10weightweight

 ControlMean442.51.103.571.46241.60.68
SD28.940.090.300.1312.890.04
 500Mean456.21.133.811.64245.50.74
SD54.930.170.210.2318.430.05
SS
 1000Mean422.30.993.511.46242.30.72
SD36.690.070.250.1415.500.05
SS
 2000Mean442.31.073.931.51238.50.71
SD61.460.150.280.1517.280.06
SS
test for significanceNSUDNDNNSDN
historical control range344-4880.97-1.502.58-4.201.39-1.93206-2850.66-0.96

DN: Duncan’s multiple range test; n: number of animals/group; NS: not significant; SD: standard deviation; SS: statistical significance; U: Mann-Whitney U-test versus control.
= p < 0.05
= p < 0.01.

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