Journal of Toxicology / 2019 / Article / Tab 9

Research Article

A Toxicological Evaluation of Mango Leaf Extract (Mangifera indica) Containing 60% Mangiferin

Table 9

Summary of histopathology findings in the 90-day study.

OrgansObservationsIncidence of observations per group
Control50010002000
mg/kg bw/daymg/kg bw/daymg/kg bw/day

Males
EpididymidesSperm granuloma (one side)0/101/1/0/10
KidneysPyelectasia0/102/22/21/10
Liver capsuleFocal fibrosis in the Glisson’s0/10//1/10
LungsAlveolar emphysema1/10//0/10
Hyperplasia of BALT1/10//1/10
Females
KidneysPyelectasia1/10/1/12/10
LiverFocal fibrosis in Glisson’s capsule0/10//1/10
LungsAlveolar emphysema1/10//0/10
Hyperplasia of BALT1/10//1/10
Bronchitis0/10//1/10
SkinAtrophy of hair follicles (focal)0/10/1/10/10
SpleenHyperplasia (focal)0/10//1/10
UterusDilatation3/10//3/10

incidence: number of animals with observations/number of animals examined
/: not examined; BALT: bronchus associated lymphoid tissue.

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