Journal of Toxicology / 2019 / Article / Tab 4

Research Article

A Toxicological Evaluation of Methylliberine (Dynamine®)

Table 4

Results of the in vivo mammalian micronucleus test.

Groups ()Sampling time (hours following final treatment)Total number of PCEs analysedMPCE (per 4000 PCE)PCE/PCE  +  NCE
Mean±SDMean±SD

Historical negative control242600005.051.00
Concurrent negative control24200006.201.300.530.02
175 mg/kg bw24200005.801.640.520.01
350 mg/kg bw24200006.201.300.500.02
700 mg/kg bw24200006.801.300.490.01
Positive control (60 mg/kg bw)2420000141.005.960.390.05

Historical negative control . to the historical negative control (value was inside in the 95% control limits (2.87–7.23) of the historical control data). to the concurrent and historical negative control.

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