Journal of Toxicology / 2019 / Article / Tab 5

Research Article

A Toxicological Evaluation of Methylliberine (Dynamine®)

Table 5

Body weight gain in the 90-day study.

Group (mg/kg bw/day)Body weight gain (g) between days
Treatment periodRecovery Period
0–44–77–1111–1414–1818–2121–2525–2828–3535–4242–4949–5656–6363–7070–7777–8484–890–8990–9797–104104–111111–11790–117

Male
0 (Control)Mean27.317.724.114.519.110.115.210.120.615.414.714.19.66.910.97.32.3239.99.84.03.410.227.4
()SD2.93.53.02.63.32.13.23.13.83.45.33.92.92.93.74.03.824.93.31.63.91.16.3
75Mean25.015.518.913.118.96.317.08.322.716.015.315.311.78.111.09.41.5234.0
SD3.74.05.22.05.63.43.62.74.95.35.44.16.24.34.03.33.136.3
SS
112Mean23.915.822.412.621.09.716.88.721.816.314.114.69.26.810.99.7−0.3234.0
SD4.73.03.72.63.92.33.92.03.57.03.47.13.74.64.74.64.420.4
SS
150Mean20.715.518.314.416.87.116.63.821.213.711.512.510.04.610.36.73.2206.9
SD5.23.92.91.64.74.52.93.54.53.75.12.63.73.35.04.73.324.9
SS
187Mean19.514.015.510.216.47.117.05.520.213.36.513.39.36.07.16.13.8190.8
SD4.43.54.34.14.85.53.53.78.13.12.94.94.25.33.23.54.527.9
SS
225Mean17.311.913.08.711.96.213.94.716.37.97.89.75.25.78.06.81.7156.515.223.415.49.663.6
()SD2.84.03.83.53.53.32.92.75.33.34.14.44.84.34.53.93.625.07.77.56.43.923.1
SS
Test for significanceDNDNDNDNDNNSDNDNDNDNDNNSNSNSNSDNNSNS
Female
0 (Control)Mean13.26.612.45.710.15.56.34.97.58.45.63.16.53.40.94.73.6108.3−0.63.2−1.01.83.4
()SD2.42.62.94.52.34.92.32.92.74.73.93.12.54.23.03.83.714.64.54.72.73.36.5
75Mean13.16.512.35.89.93.36.63.512.07.06.45.77.73.41.73.24.4112.5
SD4.13.72.83.22.52.73.33.04.03.84.45.11.73.93.94.73.68.2
SS
112Mean13.18.111.15.89.43.76.73.610.78.07.36.05.64.8−0.13.06.0112.8
SD3.83.03.62.02.73.72.53.64.13.04.93.73.93.95.12.14.112.6
SS
150Mean11.69.211.66.39.62.98.13.012.57.16.77.93.73.44.34.41.8114.1
SD2.22.92.02.41.84.02.23.63.83.52.82.12.23.03.73.62.614.8
SS
187Mean13.08.412.86.99.82.59.62.310.38.35.26.56.23.65.34.13.7118.5
SD2.11.85.32.83.23.22.42.32.51.63.32.42.34.24.02.82.617.4
SS
225Mean10.18.311.04.48.94.08.73.010.95.94.88.14.44.32.53.12.1104.6−5.44.60.40.60.2
()SD2.12.73.53.63.32.13.74.66.34.23.02.72.32.74.23.24.314.62.65.03.22.15.8
SS
Test for significanceDNNSNSNSNSNSDNNSNSNSDNDNNSDNNSNSNSNSNSNSNSNS

Abbreviations: DN, Duncan’s multiple range test; NS, not significant; SD, standard deviation; SS, statistically significant compared to control; -test versus control; , Mann-Whitney -test versus control.Recovery period . , .

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