A Toxicological Evaluation of Methylliberine (Dynamine®)
Table 5
Body weight gain in the 90-day study.
Group (mg/kg bw/day)
Body weight gain (g) between days
Treatment period
Recovery Period
0–4
4–7
7–11
11–14
14–18
18–21
21–25
25–28
28–35
35–42
42–49
49–56
56–63
63–70
70–77
77–84
84–89
0–89
90–97
97–104
104–111
111–117
90–117
Male
0 (Control)
Mean
27.3
17.7
24.1
14.5
19.1
10.1
15.2
10.1
20.6
15.4
14.7
14.1
9.6
6.9
10.9
7.3
2.3
239.9
9.8
4.0
3.4
10.2
27.4
(†)
SD
2.9
3.5
3.0
2.6
3.3
2.1
3.2
3.1
3.8
3.4
5.3
3.9
2.9
2.9
3.7
4.0
3.8
24.9
3.3
1.6
3.9
1.1
6.3
75
Mean
25.0
15.5
18.9
13.1
18.9
6.3
17.0
8.3
22.7
16.0
15.3
15.3
11.7
8.1
11.0
9.4
1.5
234.0
SD
3.7
4.0
5.2
2.0
5.6
3.4
3.6
2.7
4.9
5.3
5.4
4.1
6.2
4.3
4.0
3.3
3.1
36.3
SS
112
Mean
23.9
15.8
22.4
12.6
21.0
9.7
16.8
8.7
21.8
16.3
14.1
14.6
9.2
6.8
10.9
9.7
−0.3
234.0
SD
4.7
3.0
3.7
2.6
3.9
2.3
3.9
2.0
3.5
7.0
3.4
7.1
3.7
4.6
4.7
4.6
4.4
20.4
SS
150
Mean
20.7
15.5
18.3
14.4
16.8
7.1
16.6
3.8
21.2
13.7
11.5
12.5
10.0
4.6
10.3
6.7
3.2
206.9
SD
5.2
3.9
2.9
1.6
4.7
4.5
2.9
3.5
4.5
3.7
5.1
2.6
3.7
3.3
5.0
4.7
3.3
24.9
SS
187
Mean
19.5
14.0
15.5
10.2
16.4
7.1
17.0
5.5
20.2
13.3
6.5
13.3
9.3
6.0
7.1
6.1
3.8
190.8
SD
4.4
3.5
4.3
4.1
4.8
5.5
3.5
3.7
8.1
3.1
2.9
4.9
4.2
5.3
3.2
3.5
4.5
27.9
SS
225
Mean
17.3
11.9
13.0
8.7
11.9
6.2
13.9
4.7
16.3
7.9
7.8
9.7
5.2
5.7
8.0
6.8
1.7
156.5
15.2
23.4
15.4
9.6
63.6
(†)
SD
2.8
4.0
3.8
3.5
3.5
3.3
2.9
2.7
5.3
3.3
4.1
4.4
4.8
4.3
4.5
3.9
3.6
25.0
7.7
7.5
6.4
3.9
23.1
SS
Test for significance
DN
DN
DN
DN
DN
NS
DN
DN
DN
DN
DN
NS
NS
NS
NS
DN
NS
NS
Female
0 (Control)
Mean
13.2
6.6
12.4
5.7
10.1
5.5
6.3
4.9
7.5
8.4
5.6
3.1
6.5
3.4
0.9
4.7
3.6
108.3
−0.6
3.2
−1.0
1.8
3.4
(†)
SD
2.4
2.6
2.9
4.5
2.3
4.9
2.3
2.9
2.7
4.7
3.9
3.1
2.5
4.2
3.0
3.8
3.7
14.6
4.5
4.7
2.7
3.3
6.5
75
Mean
13.1
6.5
12.3
5.8
9.9
3.3
6.6
3.5
12.0
7.0
6.4
5.7
7.7
3.4
1.7
3.2
4.4
112.5
SD
4.1
3.7
2.8
3.2
2.5
2.7
3.3
3.0
4.0
3.8
4.4
5.1
1.7
3.9
3.9
4.7
3.6
8.2
SS
112
Mean
13.1
8.1
11.1
5.8
9.4
3.7
6.7
3.6
10.7
8.0
7.3
6.0
5.6
4.8
−0.1
3.0
6.0
112.8
SD
3.8
3.0
3.6
2.0
2.7
3.7
2.5
3.6
4.1
3.0
4.9
3.7
3.9
3.9
5.1
2.1
4.1
12.6
SS
150
Mean
11.6
9.2
11.6
6.3
9.6
2.9
8.1
3.0
12.5
7.1
6.7
7.9
3.7
3.4
4.3
4.4
1.8
114.1
SD
2.2
2.9
2.0
2.4
1.8
4.0
2.2
3.6
3.8
3.5
2.8
2.1
2.2
3.0
3.7
3.6
2.6
14.8
SS
187
Mean
13.0
8.4
12.8
6.9
9.8
2.5
9.6
2.3
10.3
8.3
5.2
6.5
6.2
3.6
5.3
4.1
3.7
118.5
SD
2.1
1.8
5.3
2.8
3.2
3.2
2.4
2.3
2.5
1.6
3.3
2.4
2.3
4.2
4.0
2.8
2.6
17.4
SS
225
Mean
10.1
8.3
11.0
4.4
8.9
4.0
8.7
3.0
10.9
5.9
4.8
8.1
4.4
4.3
2.5
3.1
2.1
104.6
−5.4
4.6
0.4
0.6
0.2
(†)
SD
2.1
2.7
3.5
3.6
3.3
2.1
3.7
4.6
6.3
4.2
3.0
2.7
2.3
2.7
4.2
3.2
4.3
14.6
2.6
5.0
3.2
2.1
5.8
SS
Test for significance
DN
NS
NS
NS
NS
NS
DN
NS
NS
NS
DN
DN
NS
DN
NS
NS
NS
NS
NS
NS
NS
NS
Abbreviations: DN, Duncan’s multiple range test; NS, not significant; SD, standard deviation; SS, statistically significant compared to control; -test versus control; , Mann-Whitney -test versus control.†Recovery period .,.
