Journal of Toxicology / 2019 / Article / Tab 6

Research Article

A Toxicological Evaluation of Methylliberine (Dynamine®)

Table 6

Results of the hematological evaluation in the 90-day study.

Group (mg/kg bw/day)WBCNEULYMMONOEOSBASORBCHGBHCTMCVMCHMCHCPLTRETPTAPTT
[×109/L][%][%][%][%][%][×1012/L][g/L][L/L][fL][pg][g/L][×109/L][%][sec][sec]
Main study groups

Male
0 (Control)Mean7.0117.7678.202.141.310.089.35160.00.4951.9417.09329.4907.81.6710.4413.54
SD1.517.287.590.660.360.060.416.90.021.010.403.578.70.290.211.13
75Mean7.6720.3274.962.811.100.089.02162.30.4954.0518.02333.5849.42.2310.4614.39
SD1.323.013.670.660.470.060.464.10.021.180.567.5104.00.290.251.05
SS
112Mean8.5825.1369.952.861.300.089.00165.000.5055.2718.36332.30896.202.7410.1013.91
SD2.1915.4515.920.690.520.040.303.230.011.670.613.8375.650.520.241.52
SS
150Mean9.2229.5165.602.811.420.099.09168.500.5155.7918.55332.50882.802.7310.1213.62
SD2.8312.0614.000.741.810.070.456.100.022.380.824.14121.320.370.161.63
SS
187Mean9.0826.5769.043.000.770.119.01168.500.5257.2718.71327.00896.703.1510.2715.17
SD1.993.613.810.500.200.030.304.330.021.310.434.45115.590.300.260.87
SS
225Mean7.8931.9663.343.040.940.099.07170.100.5257.3518.81327.90933.903.2710.2315.17
SD2.399.4310.881.200.420.030.536.690.022.360.835.9584.100.320.211.46
SS
Test for significanceNSNSNSNSDNDNDNDNNSNSDNDNDN
Historical control Range4.3–10.610-3–35.760.1–86.51.2–6.70.7–2.80.0–0.28.1–9.9145.0–183.00.4–0.549.9–60.216.3–20.7315.0–361.0339.0–1062.01.2–2.310.0–11.210.2–15.6

Female
0 (Control)Mean4.9121.0374.112.521.890.088.41154.60.4655.1618.39333.6886.71.739.9113.35
SD1.7213.7414.850.670.960.060.274.60.011.140.445.5174.70.360.211.28
75Mean5.9817.5378.142.641.140.078.12150.80.4656.8518.59327.2905.82.559.9315.15
SD1.654.213.880.760.590.050.354.90.021.320.748.0104.70.400.371.17
SS
112Mean6.2718.4177.832.370.910.078.22152.10.4655.4718.52333.6947.72.849.8815.19
SD1.805.205.120.520.160.050.418.70.020.840.588.097.70.380.091.11
SS
150Mean7.2422.4473.932.500.610.068.14153.40.4657.0818.86330.4927.53.049.8514.37
SD1.184.073.920.310.100.050.313.70.011.130.504.8115.80.420.201.28
SS
187Mean7.3922.0074.212.580.600.108.19151.40.4656.6018.52327.2967.43.279.8013.67
()SD1.487.117.310.840.140.000.469.20.021.880.595.7100.80.390.221.46
SS
225Mean7.5325.6870.032.960.740.068.21153.40.4656.3718.72332.01013.43.159.8514.14
SD1.4912.3413.370.960.400.050.365.70.011.490.685.394.20.530.130.91
SS
Test for significanceDNNSNSNSNSNSDNNSDNNSDNNSDN
Historical control range1.5–9.27.6–50.243.7–88.71.0–5.00.8–3.70.0–0.27.4–10.1141.0–175.00.4–0.550.1–57.717.2–20.1319.0–365.0450.0–1127.01.2–3.69.5–10.511.1–16.1
Recovery groups
Male
0 (Control)Mean7.3018.0276.323.061.900.128.88156.400.4853.3217.60330.2786.41.6310.6812.22
SD2.264.503.981.831.080.040.397.920.020.830.238.0155.90.210.201.19
225Mean7.8819.9875.063.041.280.128.56159.200.5057.8018.62321.8758.62.4710.7012.96
SD0.635.235.700.880.330.040.273.700.021.240.402.2119.50.300.220.54
SS
Test for significanceNSNSNSNSNSNSNSNSNSNSNSNSNS
Female
0 (Control)Mean4.2025.4868.942.522.620.088.68155.200.4854.8217.88326.0740.42.2210.1013.14
SD1.415.244.700.472.060.080.344.920.020.950.417.9169.50.200.331.06
225Mean5.1820.8075.422.081.160.088.69156.600.4854.9218.04328.4863.01.7810.1214.32
SD1.065.565.420.460.180.040.454.980.021.400.514.3145.60.380.130.57
Test for significanceNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNS

Abbreviations: APTT, activated partial thromboplastin time; BASO, basophil granulocytes; DN, Duncan’s multiple range test; EOS, eosinophil granulocytes; HCT, hematocrit; HGB, hemoglobin; LYM, lymphocyte; MCV, mean corpuscular volume; MCH, mean corpuscular hemoglogin; MCHC, mean corpuscular hemoglobin concentration; MONO, monocyte; NEU, neutrophil granulocytes; NS, not significant; PLT, platelet count; PT prothrombin time; RBC, red blood cell (erythrocyte); RET, reticulocyte; SD, standard deviation; SS, statistically significant compared to control; -test versus control; , Mann-Whitney -test versus control; WBC, white blood cell. Main group females at 187 mg/kg bw/day (; one animal died at collection due to over anesthesia). , .

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