Histological, Biochemical, and Hematological Effects of Goniothalamin on Selective Internal Organs of Male Sprague-Dawley Rats
Table 1
Haematological evaluation for acute toxicity.
Control
100mg/kg
200mg/kg
300mg/kg
400mg/kg
500mg/kg
Hemoglobin (g/dL)
16.52 ± 1.22
15.46 ± 1.12
15.62 ± 1.31
15.12 ± 2.21
16.13 ± 1.46
15.11 ± 2.08
White blood cells (109/L)
6.33 ± 0.32
6.11 ± 0.52
6.61 ± 0.58
5.99 ± 1.14
6.47 ± 053
5.71 ± 1.21
Neutrophils (109/L)
18.22 ± 0.23
18.41 ± 0.31
17.17 ± 2.35
17.22 ± 3.15
17.30 ± 0.50
18.33 ± 1.21
Lymphocyte (109/L)
78.21 ± 2.26
80.16 ± 5.31
76.86 ± 2.17
80.66 ± 3.11
79.23 ± 1.11
76.57 ± 1.55
Monocytes (109/L)
0.89 ± 0.11
1.00 ± 0.10
0.87 ± 0.12
0.87 ± 0.21
0.85 ± 0.12
0.88 ± 0.10
Eosinophils (109/L)
3.23 ± 3.68
3.13 ± 2.79
3.41 ± 3.21
3.22 ± 2.31
3.11 ± 2.45
3.51 ± 2.55
Basophils (109/L)
0.01 ± 0.21
0.01 ± 0.11
0.01 ± 0.02
0.01 ± 0.07
0.01 ± 0.10
0.01 ± 0.06
The results are expressed as the mean ±Standard error, (n=7). No significant difference could be detected between the different groups vs. the control group; Control, normal control group; 100 mg/kg, 100 mg/kg GTN- intraperitoneal treated group; 200 mg/kg, 200 mg/kg GTN- intraperitoneal treated group; 300 mg/kg, 300 mg/kg GTN- intraperitoneal treated group; 400 mg/kg, 400 mg/kg GTN- intraperitoneal treated group; 500 mg/kg, 500 mg/kg GTN- intraperitoneal treated group.
