An Adverse Outcome Pathway Linking Organohalogen Exposure to Mitochondrial Disease

Figure 3

Graphical representation of organohalogen exposure to mitochondrial disease AOP. Key events at the molecular and cellular levels lead to AOs at the tissue/organ and individual levels. Exposure to organohalogens cause increased ROS production (Molecular Initiating Event, MIE), triggering the key events (KEs) that result in the adverse outcome (AO), defined as the onset of mitochondrial disease and the associated symptoms of organ symptom dysfunction. This AOP depicts 2 distinct pathways from MIE to AO.