Research Article
Acute, Subacute, and Genotoxicity Assessments of a Proprietary Blend of Garcinia mangostana Fruit Rind and Cinnamomum tamala Leaf Extracts (CinDura®)
Table 12
Summary of histopathological observations on the vital organs of female Wistar rats after 28 days of oral supplementation of GMCT.
| Organs/findings | Number of animals showing abnormal findings (severity score) | GMCT dose (mg/kg/day) | 0 (G1) | 1000 (G4) |
| Adrenals | Cortical tissue, accessory | 1 (+) | 2 (+) | Kidneys | Mineralization, tubular, outer medulla | 0 | 1 (+) | Liver | 0 | 0 | Lungs | Mineralization | 1 (+) | 0 | Alveolar infiltration, MNC, perivascular | 1 (+) | 0 | Pituitary gland | Pseudocyst, pars intermedia | 0 | 1 (+) | Thymus | 0 | 0 | Haemorrhage, medulla | 1 (+) | 0 | Necrosis, lymphocytes, cortex | 1 (++) | 0 | Thyroid | Thymic tissue, ectopic | 1 (+) | 0 | Trachea | Glandular dilation, submucosal | 0 | 1 (+) | Uterus | Luminal dilatation (proestrous stage) | 1 (+) | 1 (+) |
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n = 5; scores (+) and (++) indicate minimal and mild abnormality, respectively.
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