Research Article

Acute, Subacute, and Genotoxicity Assessments of a Proprietary Blend of Garcinia mangostana Fruit Rind and Cinnamomum tamala Leaf Extracts (CinDura®)

Table 12

Summary of histopathological observations on the vital organs of female Wistar rats after 28 days of oral supplementation of GMCT.

Organs/findingsNumber of animals showing abnormal findings (severity score)
GMCT dose (mg/kg/day)
0 (G1)1000 (G4)

Adrenals
 Cortical tissue, accessory1 (+)2 (+)
Kidneys
 Mineralization, tubular, outer medulla01 (+)
Liver00
Lungs
 Mineralization1 (+)0
 Alveolar infiltration, MNC, perivascular1 (+)0
Pituitary gland
 Pseudocyst, pars intermedia01 (+)
Thymus00
 Haemorrhage, medulla1 (+)0
 Necrosis, lymphocytes, cortex1 (++)0
Thyroid
 Thymic tissue, ectopic1 (+)0
Trachea
 Glandular dilation, submucosal01 (+)
Uterus
 Luminal dilatation (proestrous stage)1 (+)1 (+)

n = 5; scores (+) and (++) indicate minimal and mild abnormality, respectively.