Acute, Subacute, and Genotoxicity Assessments of a Proprietary Blend of Garcinia mangostana Fruit Rind and Cinnamomum tamala Leaf Extracts (CinDura®)

Table 13

In vitro mutagenicity assay of GMCT in the Ames test.

Treatment (μg/plate)	Number of revertant colonies/plate (mean ± SD)
	TA98 (+S9)	TA98 (−S9)	TA100 (+S9)	TA100 (−S9)	TA1535 (+S9)	TA1535 (−S9)	TA1537 (+S9)	TA1537 (−S9)	WP2 uvrA/(pKM101) (+S9)	WP2 uvrA/pKM101 (−S9)
Vehicle control (0)	25.7 ± 3.1	22.3 ± 2.5	124.0 ± 3.6	123.3 ± 3.5	13.7 ± 1.5	11 ± 2	9.3 ± 2.5	6.3 ± 1.5	132.3 ± 4.9	130.3 ± 3
100	21.3 ± 3.5	22.3 ± 1.5	122.3 ± 2.5	125.3 ± 3.5	10.3 ± 1.5	11.7 ± 1.5	6.3 ± 1.5	7 ± 2	123 ± 3	124 ± 3.6
266	25.3 ± 2.5	22.7 ± 2.5	123.7 ± 3.1	124.3 ± 4	9.3 ± 2.1	8 ± 2	6.7 ± 1.5	6.3 ± 1.5	124 ± 2.6	123 ± 3.6
707	22.7 ± 2.1	21 ± 2	124.7 ± 2.5	125 ± 2	8 ± 1	8.3 ± 1.5	8 ± 2	6 ± 1	123 ± 1	124.3 ± 1.5
1880	22 ± 3.6	21 ± 3.6	123 ± 2	123.3 ± 2.5	8.7 ± 1.5	10 ± 1	7 ± 1	5.3 ± 1.5	121 ± 1	122.3 ± 2.1
5000	22.7 ± 3.5	20.7 ± 1.5	123 ± 4.4	124 ± 3.6	8.7 ± 2.1	9.3 ± 2.1	9 ± 2	5.7 ± 2.1	120.3 ± 1.5	123.3 ± 3.2
Positive control	549 ± 17.7^a	289.7 ± 13^c	880.3 ± 18.5^a	565.3 ± 14^d	142 ± 8.9^a	152.7 ± 9.3^d	142.3 ± 7.5^a	144 ± 6.6^e	575.7 ± 11.7^b	542.7 ± 9.6^f

^a2-Aminoanthracene (4 μg/plate); ^b2-aminoanthracene (30 μg/plate); ^c2-nitrofluorence (2 μg/plate); ^dsodium azide (1 μg/plate); ^e9-aminoacridine (50 μg/plate); ^f4-nitroquinoline-1-oxide (4 μg/plate).