Acute, Subacute, and Genotoxicity Assessments of a Proprietary Blend of Garcinia mangostana Fruit Rind and Cinnamomum tamala Leaf Extracts (CinDura®)

Table 2

Effect of oral administration of GMCT on feed consumption by female Wistar rats.

Feed consumption (g/week/animal)
Days	Primary groups; Dose (mg/kg/day)				Reversal groups; Dose (mg/kg/day)
	0 (G1)	250 (G2)	500 (G3)	1000 (G4)	0 (G1R)	1000 (G4R)
1–7	94.80 ± 0.51	93.68 ± 5.75	94.86 ± 0.40	96.74 ± 1.53	95.74 ± 1.48	92.84 ± 2.02^#
8–14	100.56 ± 6.62	96.00 ± 3.04	98.97 ± 1.13	101.34 ± 0.58	100.08 ± 0.41	94.27 ± 6.39
15–21	99.50 ± 3.26	105.24 ± 4.57	99.59 ± 2.53	99.89 ± 4.64	97.00 ± 2.0	96.03 ± 4.40
22–28	88.55 ± 0.65	90.29 ± 0.77	87.32 ± 0.88	90.62 ± 1.59	99.78 ± 5.04	90.12 ± 10.59
29–35	—	—	—	—	97.53 ± 5.87	101.47 ± 2.58
36–42	—	—	—	—	80.15 ± 3.37	83.16 ± 2.98
Total feed consumption from day 1 (g, mean ± SD)
	383.41 ± 11.04	385.21 ± 14.13	380.74 ± 4.94	388.59 ± 8.34	570.28 ± 18.17	557.89 ± 28.96

Data are present as mean ± SD; n = 5. and ^#Significance vs. G1 and G1R, respectively.