Acute, Subacute, and Genotoxicity Assessments of a Proprietary Blend of Garcinia mangostana Fruit Rind and Cinnamomum tamala Leaf Extracts (CinDura®)
Table 8
Effect of oral administration of GMCT on hematology parameters in female Wistar rats.
Parameters
Primary groups Dose (mg/kg/day)
Reversal groups Dose (mg/kg/day)
0 (G1)
250 (G2)
500 (G3)
1000 (G4)
0 (G1R)
1000 (G4R)
RBC (106/μL)
8.70 ± 0.35
8.81 ± 0.47
8.56 ± 0.34
8.94 ± 0.29
8.67 ± 0.55
8.75 ± 0.24
Hb (g/dL)
15.64 ± 0.97
15.78 ± 0.65
15.62 ± 0.74
15.86 ± 0.53
15.62 ± 0.91
15.66 ± 0.35
Hct (%)
47.62 ± 2.86
47.96 ± 1.25
46.82 ± 2.33
48.66 ± 1.29
47.94 ± 2.84
48.70 ± 1.03
MCV (fL)
54.7 ± 1.20
54.52 ± 2.09
54.64 ± 1.52
54.46 ± 0.99
55.30 ± 1.02
55.66 ± 0.55
MCH (pg)
17.96 ± 0.42
17.94 ± 0.48
18.22 ± 0.40
17.76 ± 0.54
18.02 ± 0.24
17.90 ± 0.51
MCHC (g/dL)
32.82 ± 0.29
32.90 ± 0.94
33.36 ± 1.03
32.62 ± 0.43
32.58 ± 0.28
32.12 ± 0.90
Plt (103/μL)
929.00 ± 46.69
806.20 ± 56.4
810.60 ± 314.78
1000.40 ± 136.02
834.80 ± 112.17
915.80 ± 102.40
WBC (103/μL)
5.32 ± 0.78
4.55 ± 1.15
5.24 ± 1.20
5.61 ± 1.20
4.85 ± 0.84
5.68 ± 1.68
Neu (%)
11.30 ± 1.77
20.82 ± 7.44
18.52 ± 12.38
12.92 ± 3.39
13.66 ± 4.42
12.38 ± 2.82
Lym (%)
84.10 ± 1.66
74.26 ± 8.23
75.96 ± 12.82
82.32 ± 3.21
81.24 ± 4.76
82.68 ± 2.88
Mono (%)
1.84 ± 0.31
2.48 ± 0.96
2.48 ± 0.50
2.20 ± 0.42
2.26 ± 0.65
2.26 ± 0.30
Eos (%)
1.98 ± 0.31
1.60 ± 0.44
2.18 ± 0.87
1.26 ± 0.23
1.74 ± 0.78
1.52 ± 0.51
Baso (%)
0.26 ± 0.09
0.24 ± 0.05
0.28 ± 0.13
0.30 ± 0.10
0.34 ± 0.09
0.28 ± 0.16
LUC (%)$
0.52 ± 0.16
0.60 ± 0.10
0.64 ± 0.11
1.00 ± 0.33
0.76 ± 0.35
0.92 ± 0.43
Rec (%)
2.32 ± 0.11
2.04 ± 0.17
2.16 ± 0.26
2.46 ± 0.38
2.50 ± 0.40
2.28 ± 0.23
CT (sec)
136.60 ± 25.55
144.60 ± 21.07
146.00 ± 13.80
142.60 ± 32.55
118.00 ± 14.58
122.60 ± 9.29
Data are present as mean ± SD; n = 5. vs. G1. $The mean ± SD of the historical normal values (%) of large unstained cells (LUC) is 1.20 ± 0.6 (min. 0.3%; max. 4.0%).
