Protective Effect of DPPD on Mercury Chloride-Induced Hepatorenal Toxicity in Rats

Table 1

Kidney injury parameters. Values are expressed as M ± SD of 10 animals in each group.

Variables	Control group	HgCl2 group	HgCl2 + DPPD group
Serum:
Creatinine (mg/dl)	0.46 ± 0.03	1.53 ± 0.21^a	0.57 ± 0.10^b
Urea (mg/dl)	27.83 ± 3.60	73.43 ± 5.87^a	32.23 ± 2.30^b
Uric acid (mg/dI)	2.57 ± 0.25	4.53 ± 0.76^a	3.16 ± 0.98^a,b
Homogenate:
Hydroxyproline (ug/mg tissue)	22.58 ± 0.63	41.23 ± 9.25^a	30.24 ± 5.23^a,b
MDA (mmol/g tissue)	59.79 ± 4.99	92.25 ± 13.05^a	70.62 ± 9.69^b
SOD (U/mg protein)	11.66 ± 0.64	6.71 ± 1.51^a	9.63 ± 1.48^a,b
CAT (mol/min/gm)	0.66 ± 0.09	0.35 ± 0.05^a	0.58 ± 0.09^b
Glutathione (μmol/g protein)	32.13 ± 2.07	21.71 ± 6.22^a	28.21 ± 3.51^b
TGF-β (ng/ml)	33.27 ± 3.43	49.20 ± 9.10^a	38.60 ± 9.19^b
CD4 (ng/ml)	21.42 ± 1.04	43.70 ± 5.31^a	34.30 ± 5.01^a,b
CD8 (ng/ml)	23.62 ± 3.88	44.06 ± 6.77^a	25.66 ± 3.87^b

SD: standard deviation; P : probability; significance <0.05; high significance. The test used is one-way ANOVA followed by post hoc Tukey. ^aSignificance relative to the control group compared with HgCl₂ and HgCl₂ + DPPD groups. ^bSignificance between the HgCl₂ group and HgCl₂ + DPPD group.