Research Article
A Toxicological Evaluation of Germanium Sesquioxide (Organic Germanium)
Table 12
Summary of histopathology, 90-day study.
| | Organs | Group‡ mg/kg bw/day | Control | 500 | 1000 | 2000 | | Observations | (# with observation/# observed) |
| | Males | Animals without microscopic findings | 9/10 | N/A | N/A | 4/10 | | Cecum | Dilatation | 0/10 | — | — | 1/10 | | Epididymides | Sperm granuloma | 0/10 | 1/1 | — | 0/10 | | Kidneys | Pyelectasia | 0/10 | 1/1 | 1/1 | 2/10 | | Cyst | 1/10 | 0/1 | 0/1 | 0/10 | | Liver | Congestion | 0/10 | — | — | 1/10 | | Lungs | Alveolar emphysema | 1/10 | — | — | 1/10 | | Hyperplasia of BALT | 1/10 | — | — | 0/10 | | Skin | Atrophy of hair follicles | 0/10 | 1/1 | — | 0/10 | | Spleen | Hyperplasia | 0/10 | — | — | 1/10 | | Thymus | Acute hemorrhage | 0/10 | 1/1 | — | 0/10 |
| | Females | Animals without microscopic findings | 6/10 | N/A | N/A | 8/10 | | Kidneys | Pyelectasia | 0/10 | 1/1 | — | 0/10 | | Hydronephrosis | 1/10 | 0/1 | — | 0/10 | | Lungs | Alveolar emphysema | 1/10 | — | — | 0/10 | | Acute hemorrhage | 1/10 | — | — | 0/10 | | Skin | Atrophy of hair follicles (focal) | 1/10 | — | — | 0/10 | | Thymus | Acute hemorrhage | 1/10 | — | 1/1 | 2/10 | | Uterus | Dilatation | 6/10 | — | 1/1 | 0/10 |
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Abbreviations: BALT: bronchus-associated lymphoid tissue; N/A: not applicable. ‡n = 10 for all groups.
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