A Toxicological Evaluation of Germanium Sesquioxide (Organic Germanium)

Table 4

Summary of mouse micronucleus test results.

Groups mg/kg bw n = 5	Sampling time (hours)	Total number of PCE analyzed	PCE/PCE + NCE		MPCE§
			Mean	±SD	Mean	±SD
Vehicle control^‡	24	20000	0.53	0.01	5.00	1.00
Test item^‡
500	24	20000	0.51	0.01	5.20	1.30
1000	24	20000	0.50	0.01	4.80	0.84
2000	24	20000	0.49	0.01	5.00	1.00
Positive control	24	20000	0.36	0.06	128.60	4.56
Historical vehicle control	24	4000	n/a	n/a	4.77	0.94

Abbreviations: MPCE: micronucleated polychromatic erythrocytes; NCE: normochromatic erythrocytes; PCE: polychromatic erythrocytes. Vehicle control: 1% aqueous methylcellulose; Positive control: 60 mg/kg bw cyclophosphamide. . §MPCE per 4000 PCE. ‡dosing occurred twice in 24 hours.