A Toxicological Evaluation of Germanium Sesquioxide (Organic Germanium)

Table 5

Summary of body weight (males), 90-day study.

Group^‡ mg/kg bw/day		Body weight (g) on days
		0	3	7	10	14	17	21	24	28	35	42	49	56	63	70	77	84	89
Control	Mean	237.4	249.8	273.7	280.1	302.4	309.9	329.5	334.7	351.7	371.9	388.3	403.0	416.2	425.4	432.7	443.2	446.0	451.6
	SD	12.7	15.6	18.2	21.0	23.7	22.5	25.5	25.9	27.0	28.1	31.4	31.4	33.2	37.4	35.2	37.9	35.2	37.9
500	Mean	240.7	255.3	281.0	288.5	311.6	315.5	335.9	343.7	358.0	376.4	390.6	404.6	418.6	427.9	437.8	444.2	445.5	451.1
	SD	12.2	12.6	14.6	14.7	16.7	17.2	18.1	18.8	20.4	19.8	19.1	21.5	21.4	23.4	25.3	22.0	23.3	23.5
1000	Mean	234.0	252.1	276.3	284.7	305.4	312.8	329.1	336.3	346.9	367.2	381.0	393.9	405.7	417.0	423.5	429.0	431.2	438.8
	SD	11.1	14.8	20.0	21.1	24.5	27.0	31.1	32.6	35.6	39.0	41.6	43.2	42.9	48.2	48.8	51.1	53.9	54.4
2000	Mean	234.0	249.9	272.3	279.2	298.8	300.8	318.5	323.0	333.3	350.2	360.4	369.0	379.9	389.9	401.5	407.2	412.8	410.8
	SD	10.3	12.1	14.8	16.3	19.2	18.6	21.8	23.6	24.8	28.6	32.3	37.0	38.6	35.1	30.3	28.2	30.1	30.5
	SS
Test for significance		NS	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS	DN	DN	NS	NS	NS	NS	DN

Abbreviations: DN: Duncan’s multiple range test; NS: not significant; SD: standard deviation; SS: statistical significance. ^‡n = 10 for all groups. .