A Toxicological Evaluation of Germanium Sesquioxide (Organic Germanium)

Table 8

Summary of relevant^a hematology results, 90-day study.

Group^‡ mg/kg bw/day		EOS (%)	MCV (fL)	PLT (×10^9/L)	RET (%)
Males
Control	Mean	2.07	54.28	679.0	1.80
	SD	0.56	2.32	150.0	0.20
500	Mean	2.48	52.44	739.1	1.60
	SD	3.12	1.50	154.1	0.15
	SS
1000	Mean	1.79	53.98	741.3	1.54
	SD	1.02	1.51	90.4	0.24
	SS
2000	Mean	1.21	53.02	818.4	1.55
	SD	0.28	1.72	111.4	0.34
	SS
Test for significance		U	DN	NS	DN
Historical control range		0.3–9.0	45.4–53.7	595–957	2.05–4.65
Females
Control	Mean	2.23	55.63	707.2	2.18
	SD	0.84	1.56	151.8	0.34
500	Mean	1.64	55.32	786.3	1.93
	SD	0.81	1.36	136.1	0.36
1000	Mean	1.49	53.97	892.6	1.80
	SD	0.37	1.43	100.1	0.40
	SS
2000	Mean	1.52	54.69	849.4	1.90
	SD	0.81	1.97	109.3	0.34
	SS
Test for significance		NS	NS	DN	NS
Historical control range		0.4–2.1	47.0–60.1	549–1103	2.77–5.63

Abbreviations: EOS: eosinophils; DN: Duncan’s multiple range test; MCV: mean corpuscular volume; NS: nonsignificant; PLT: platelets; RET: reticulocytes; SD: standard deviation; SS: statistical significance; U: Mann–Whitney U-test versus control. ^a Only statistically significant findings are shown. ^‡n = 10 for all groups. , .