Evaluation of 1-Propanol Toxicity in B6C3F1 Mice via Repeated Inhalation over 28 and 90 Days

Table 2

Hematological data from B6C3F1 mice exposed to inhaled 1-propanol over 90 days.

Parameters	Control (0 ppm)	T1 (500 ppm)	T2 (1600 ppm)	T3 (5200 ppm)
Male
WBC (×10^3/μL)	3.505 ± 1.441	3.392 ± 1.396	3.334 ± 0.814	3.164 ± 1.268
RBC (×10^6/μL)	9.827 ± 0.361	9.643 ± 0.194	9.421 ± 0.319	9.676 ± 0.273
HCT (%)	47.83 ± 1.474	46.89 ± 1.176	46.37 ± 1.714	46.89 ± 1.103
MCHC (g/dL)	30.97 ± 0.546	31.09 ± 0.468	31.01 ± 0.545	31.30 ± 0.457
RET (×10^3/μL)	242.2 ± 53.06	259.1 ± 20.23	253.0 ± 21.17	261.7 ± 24.73
PLT (×10^3/μL)	1106.9 ± 114.7	1101.7 ± 51.3	1090.2 ± 134.1	1103.8 ± 42.8
HGB (g/dL)	14.82 ± 0.587	14.56 ± 0.313	14.38 ± 0.405	14.67 ± 0.337
MCH (pg)	15.07 ± 0.216	15.12 ± 0.172	15.27 ± 0.216	15.14 ± 0.196
MCV (fL)	48.67 ± 0.683	48.60 ± 0.485	49.23 ± 0.760	48.46 ± 0.781
NEU (%)	14.28 ± 4.750	12.59 ± 3.883	14.26 ± 3.553	19.03 ± 9.011
LYM (%)	79.29 ± 5.539	82.21 ± 4.405	80.17 ± 4.120	74.10 ± 8.628
MON (%)	2.03 ± 0.521	1.77 ± 0.669	1.67 ± 0.400	1.69 ± 0.378
EOS (%)	2.98 ± 0.890	2.49 ± 0.685	2.64 ± 1.329	3.90 ± 0.667
BAS (%)	0.24 ± 0.097	0.24 ± 0.124	0.44 ± 0.693	0.27 ± 0.170
Female
WBC (×10^3/μL)	1.838 ± 0.842	2.163 ± 0.799	2.310 ± 1.071	2.519 ± 0.126
RBC (×10^6/μL)	9.684 ± 0.303	9.688 ± 0.371	9.719 ± 0.436	8.774 ± 3.007
HCT (%)	47.85 ± 1.428	47.37 ± 1.491	47.63 ± 1.947	43.19 ± 14.79
MCHC (g/dL)	31.16 ± 0.530	31.65 ± 0.474	31.65 ± 0.251	29.23 ± 6.143
RET (×10^3/μL)	239.4 ± 48.84	240.9 ± 47.94	224.8 ± 27.56	199.3 ± 88.41
PLT (×10^3/μL)	1011.3 ± 53.8	1033.4 ± 38.3	960.2 ± 30.4	905.2 ± 614.2
HGB (g/dL)	14.88 ± 0.399	14.99 ± 0.472	15.08 ± 0.641	13.42 ± 4.855
MCH (pg)	15.39 ± 0.367	15.48 ± 0.193	15.51 ± 0.137	14.38 ± 3.031
MCV (fL)	49.42 ± 0.590	48.91 ± 0.785	49.03 ± 0.501	49.21 ± 0.685
NEU (%)	24.50 ± 7.461	24.35 ± 9.212	24.61 ± 5.922	21.70 ± 6.996
LYM (%)	68.98 ± 7.815	68.73 ± 7.732	69.17 ± 5.262	69.92 ± 6.515
MON (%)	2.03 ± 0.521	1.77 ± 0.669	1.67 ± 0.400	1.69 ± 0.378
EOS (%)	3.28 ± 1.164	4.19 ± 2.906	2.92 ± 1.570	4.66 ± 1.821
BAS (%)	0.57 ± 0.430	0.22 ± 0.148	0.41 ± 0.321	0.39 ± 0.232

Values are expressed as mean ± SD. Significant difference from controls at . WBC, white blood cell count; RBC, red blood cell count; HCT, hematocrit; MCHC, mean corpuscular hemoglobin concentration; RET, reticulocyte; PLT, platelet; HGB, hemoglobin; MCH, mean corpuscular hemoglobin; MCV, mean corpuscular volume; NEU, neutrophil, LYM, lymphocyte; MON, monocyte; EOS, eosinophil; BAS, basophil.