Research Article

Protective Effects of Hydroalcoholic Extract of Rosa canina Fruit on Vancomycin-Induced Nephrotoxicity in Rats

Table 1

Effect of RC extract on oxidative stress markers in VAN-treated rat kidney.

GroupstSH (μmol/g tissue)PCO (μmol/g tissue)NO metabolites (μmol/g tissue)MDA (μmol/g tissue)

Control18.65 ± 1.5213.55 ± 1.0128.83 ± 5.442.30 ± 0.34
VAN12 ± 2.0131.77 ± 2.1353.61 ± 3.124.42 ± 0.16
VAN + RC 250 mg/kg16.63 ± 2.0130.37 ± 1.6439.30 ± 1.933.22 ± 0.13#
VAN + RC 500 mg/kg15.6 ± 1.2122.97 ± 2.21#33.69 ± 2.01#2.31 ± 0.04#
RC 500 mg/kg19.29 ± 2.1920.47 ± 1.0230.08 ± 1.782.50 ± 0.13

tSH, total thiol content; PCO, protein carbonyl; NO, nitric oxide metabolites; MDA, malondialdehyde; VAN, vancomycin; RC, Rosa canina. Each value represents the mean ± SEM. Statistically significant compared to the control group (); #statistically significant compared to the VAN group ().