Role of Shear Stress on Renal Proximal Tubular Cells for Nephrotoxicity Assays

Figure 1

Varying conditions used to expose PTC to shear stress in vitro. The graph illustrates the varying intensity and duration of shear stress applied to cultured PTC from 25 reports in the literature. The y-axis is the intensity of shear force in dynes/cm², and the x-axis is the duration of the exposure in hours. When a report used multiple of conditions, arrows indicate the range of intensities, and/or times and the marker is placed at the average value. Each publication is indicated with a number which corresponds to the citation in Table 1. The marker shape indicates the method used to apply the fluid shear stress: blue squares are parallel plates and microfluidics, red circles are rotating wall suspension culture, and green triangles are stirring bioreactors and orbital shakers.