Comparison of In Vitro Endocrine Activity of Phthalates and Alternative Plasticizers

Figure 7

Antiandrogenic activity of phthalate substitutes in MDA-kb2 cells. MDA-kb2 cells were exposed for 20–24 h to different concentrations of (a) DEHT, DINCH, or TOTM or (b) POLYSORB® isosorbide or POLYSORB® ID 46 or the reference antiandrogen hydroxyflutamide (HF) together with 0.25 nM DHT. Results represent the mean relative luciferase activity compared to the solvent control with 0.25 nM DHT (=100%) ±SD of 3 replicates from one representative assay out of 2 assays.

(a)

(b)