Journal of Toxicology

State of the Science: Biologically Based Modeling in Risk Assessment


Publishing date
21 Apr 2012
Status
Published
Submission deadline
21 Oct 2011

1National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Washington, DC, USA

2Department of Occupational and Environmental Health, University of Montreal, Montreal, QC, Canada

3National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA


State of the Science: Biologically Based Modeling in Risk Assessment

Description

Biologically based modeling has been a critical step in human risk assessment of pharmacologic and environmental chemical exposures. Physiologically Based Pharmacokinetic (PBPK) models are used for predictions of an internal or target dose from external exposures. However, each risk assessment is dependent on the nature of the animal and human databases to support extrapolations across species, experimental paradigms, and variability of response within human populations. With an increased emphasis on the development of computational toxicology models using paradigms farther removed from physiological exposures, whole organism responses, and long-term health outcomes, a challenge arises for the integration of the state-of- the-art science PBPK modeling with emerging and current risk assessment paradigms. We will take a particular interest in original manuscripts that highlight application of cutting-edge PBPK models and analyses that can provide the basis for future modeling efforts and provide bridges to emerging toxicology paradigms. Potential topics include, but are not limited to:

  • Increased understanding of human variability of pharmacokinetics and pharmacodynamics in the population
  • Exploration of rodent mode of action hypotheses
  • Application of biological modeling in the risk assessment of individual and mixtures of chemicals
  • Identifying and addressing uncertainties in the modeling process

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jt/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2012
  • - Article ID 758182
  • - Editorial

State of the Science: Biologically Based Modeling in Risk Assessment

Jane C. Caldwell | Kannan Krishnan | Marina V. Evans
  • Special Issue
  • - Volume 2012
  • - Article ID 852384
  • - Review Article

Cutting Edge PBPK Models and Analyses: Providing the Basis for Future Modeling Efforts and Bridges to Emerging Toxicology Paradigms

Jane C. Caldwell | Marina V. Evans | Kannan Krishnan
  • Special Issue
  • - Volume 2012
  • - Article ID 629781
  • - Research Article

Physiologically Based Pharmacokinetic (PBPK) Modeling of Metabolic Pathways of Bromochloromethane in Rats

W. S. Cuello | T. A. T. Janes | ... | M. V. Evans
  • Special Issue
  • - Volume 2012
  • - Article ID 286079
  • - Research Article

Quantitative Property-Property Relationship for Screening-Level Prediction of Intrinsic Clearance of Volatile Organic Chemicals in Rats and Its Integration within PBPK Models to Predict Inhalation Pharmacokinetics in Humans

Thomas Peyret | Kannan Krishnan
  • Special Issue
  • - Volume 2012
  • - Article ID 359471
  • - Review Article

Physiologically Based Toxicokinetic Modelling as a Tool to Support Risk Assessment: Three Case Studies

Hans Mielke | Ursula Gundert-Remy
  • Special Issue
  • - Volume 2012
  • - Article ID 791431
  • - Research Article

Update on a Pharmacokinetic-Centric Alternative Tier II Program for MMT—Part II: Physiologically Based Pharmacokinetic Modeling and Manganese Risk Assessment

Michael D. Taylor | Harvey J. Clewell | ... | David C. Dorman
  • Special Issue
  • - Volume 2012
  • - Article ID 959070
  • - Research Article

Short Communication: Is Ethanol-Based Hand Sanitizer Involved in Acute Pancreatitis after Excessive Disinfection?—An Evaluation with the Use of PBPK Model

Céline Huynh-Delerme | Catherine Artigou | ... | Catherine Desmares
  • Special Issue
  • - Volume 2012
  • - Article ID 760281
  • - Research Article

Reconstruction of Exposure to m-Xylene from Human Biomonitoring Data Using PBPK Modelling, Bayesian Inference, and Markov Chain Monte Carlo Simulation

Kevin McNally | Richard Cotton | ... | George Loizou
  • Special Issue
  • - Volume 2012
  • - Article ID 946742
  • - Review Article

Update on a Pharmacokinetic-Centric Alternative Tier II Program for MMT—Part I: Program Implementation and Lessons Learned

David C. Dorman | Melvin E. Andersen | ... | Michael D. Taylor
  • Special Issue
  • - Volume 2012
  • - Article ID 904603
  • - Review Article

Application of Physiologically Based Pharmacokinetic Models in Chemical Risk Assessment

Moiz Mumtaz | Jeffrey Fisher | ... | Patricia Ruiz
Journal of Toxicology
 Journal metrics
Acceptance rate35%
Submission to final decision113 days
Acceptance to publication61 days
CiteScore3.400
Impact Factor-
 Submit

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.