Table of Contents
Journal of Theoretical Chemistry
Volume 2013, Article ID 313419, 10 pages
Research Article

Theoretical Investigation of the D83V Mutation within the Myocyte-Specific Enhancer Factor-2 Beta and Its Role in Cancer

1Genome Sciences Centre, BC Cancer Agency, Suite 100 570 West 7th Avenue, Vancouver, BC, Canada
2Department of Biochemistry and Molecular Biology, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC, Canada

Received 26 March 2013; Accepted 21 October 2013

Academic Editors: S. W. Rick and H. Verli

Copyright © 2013 Oleksandr Yakovenko et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Material: FigS1. Collection of individual PMFs along the reaction coordinate of s3 loops unfolding for D-model (blue), C-model (cyan), N-model (green), V-model (red), A-model (orange) and G-model (yellow). The pulling is performed under slightly different temperatures Tp=300K, 305K, 310K and 315K. Each of pulling trajectories was sampled under slightly different temperatures Tu=300K, 305K, 310K and 315K. a, PFM of s3/1 loops melting. b, PMF of s3/2 loops melting.

  1. Supplementary Material