Clinical Study

Adherence to Artesunate-Amodiaquine Therapy for Uncomplicated Malaria in Rural Ghana: A Randomised Trial of Supervised versus Unsupervised Drug Administration

Table 4

Proportion of participants with high (  grade 3 CTCAE v3 classification) haematological and biochemical indices at Days 0 and 2.

Biochemical assessmentDay 0Day 2

SupervisedUnsupervised valueSupervisedUnsupervised value
( ) ( ) ( ) ( )
Hemoglobin1 (0.47)3 (1.58).263 (1.42)5 (2.63).07
Alanine transaminase1 (0.54)1 (0.60).941 (0.54)1 (0.60).94
Aspartate transaminase1 (0.48)2 (1.06).500 (0.00)3 (1.96)
Total bilirubin4 (1.96)3 (1.62).254 (2.06)7 (4.02).27
Urea1 (0.48)1 (0.53).947 (3.72)4 (2.34).45
Creatinine3 (1.42)1 (0.53).3723 (11.22)16 (8.74).44

Note: The proportion of high creatinine was similar among the two groups at days 0 and 2; there was a significant increase by Day 2 compared with day 0 among both supervised ( ) and unsupervised ( ) groups.