Case Report

Fatal Plasmodium falciparum, Clostridium perfringens, and Candida spp. Coinfections in a Traveler to Haiti

Figure 1

Histopathologic and immunohistochemical findings in representstive tissues of study patient. (a) Extensive necrosis of intestinal mucosa with diffuse, extensive, submucosal edema and multifocal inflammatory cell infiltrates (H&E, original magnification X13). (b) Abundant, diffuse immunostaining of Clostridium spp. antigens in intestine (original magnification X13; inset X100). (c) Immunohistochemical detection of P. falciparum HRP-2 antigens in pRBCs in spleen (original magnification X100). (d) HRP-2 antigen immunostaining in endothelium of CNS blood vessels (original magnification X50).