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Journal of Tropical Medicine
Volume 2011, Article ID 628435, 11 pages
http://dx.doi.org/10.1155/2011/628435
Review Article

Matrix Metalloproteinase-9 and Haemozoin: Wedding Rings for Human Host and Plasmodium falciparum Parasite in Complicated Malaria

Dipartimento di Genetica, Biologia e Biochimica, Facoltà di Medicina e Chirurgia, Università di Torino, Via Santena 5 bis, 10126 Torino, Italy

Received 31 December 2010; Accepted 7 March 2011

Academic Editor: Sasithon Pukrittayakamee

Copyright © 2011 Mauro Prato and Giuliana Giribaldi. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

It is generally accepted that the combination of both Plasmodium falciparum parasite and human host factors is involved in the pathogenesis of complicated severe malaria, including cerebral malaria (CM). Among parasite products, the malarial pigment haemozoin (HZ) has been shown to impair the functions of mononuclear and endothelial cells. Different CM models were associated with enhanced levels of matrix metalloproteinases (MMPs), a family of proteolytic enzymes able to disrupt subendothelial basement membrane and tight junctions and shed, activate, or inactivate cytokines, chemokines, and other MMPs through cleavage from their precursors. Among MMPs, a good candidate for targeted therapy might be MMP-9, whose mRNA and protein expression enhancement as well as direct proenzyme activation by HZ have been recently investigated in a series of studies by our group and others. In the present paper the role of HZ and MMP-9 in complicated malaria, as well as their interactions, will be discussed.