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Journal of Tropical Medicine
Volume 2012, Article ID 301808, 6 pages
Review Article

Contact Investigation of Children Exposed to Tuberculosis in South East Asia: A Systematic Review

1Department of Paediatrics, Faculty of Medicine, Gadjah Mada University, Yogyakarta 55284, Indonesia
2Centre for International Child Health, Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children's Hospital, University of Melbourne, Melbourne, VIC 3052, Australia
3Department of Respiratory Medicine, Royal Children's Hospital, Melbourne, VIC 3052, Australia
4Center for International Health, University of Otago, Dunedin 9050, New Zealand
5Department of Public Health, Faculty of Medicine, Gadjah Mada University, Yogyakarta 55281, Indonesia
6Child Lung Health, International Union Against Tuberculosis and Lung Disease, 75006 Paris, France

Received 17 August 2011; Revised 30 September 2011; Accepted 2 October 2011

Academic Editor: Abu Syed Golam Faruque

Copyright © 2012 Rina Triasih et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Screening of children who are household contacts of tuberculosis (TB) cases is universally recommended but rarely implemented in TB endemic setting. This paper aims to summarise published data of the prevalence of TB infection and disease among child contacts in South East Asia. Methods. Search strategies were developed to identify all published studies from South East Asia of household contact investigation that included children (0–15 years). Results. Eleven studies were eligible for review. There was heterogeneity across the studies. TB infection was common among child contacts under 15 years of age (24.4–69.2%) and was higher than the prevalence of TB disease, which varied from 3.3% to 5.5%. Conclusion. TB infection is common among children that are household contacts of TB cases in South East Asia. Novel approaches to child contact screening and management that improve implementation in South East Asia need to be further evaluated.