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Journal of Tropical Medicine
Volume 2012, Article ID 818219, 12 pages
http://dx.doi.org/10.1155/2012/818219
Review Article

Classic and New Diagnostic Approaches to Childhood Tuberculosis

1Interinstitutional Posgrade in Science and Technology, Research Center in Technology and Design Assistance of Jalisco State (CIATEJ, AC), National Council of Science and Technology (CONACYT), 44270 Guadalajara, JAL, Mexico
2Molecular Biology Laboratory, Biosecurity Area, Pharmaceutical and Medical Biotechnology Unit, Research Center in Technology and Design Assistance of Jalisco State (CIATEJ, AC), National Council of Science and Technology (CONACYT), 44270 Guadalajara, JAL, Mexico

Received 16 October 2011; Revised 28 December 2011; Accepted 2 January 2012

Academic Editor: Mohammod Jobayer Chisti

Copyright © 2012 Gladys Guadalupe López Ávalos and Ernesto Prado Montes de Oca. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Tuberculosis in childhood differs from the adult clinical form and even has been suggested that it is a different disease due to its differential signs. However, prevention, diagnostics, and therapeutic efforts have been biased toward adult clinical care. Sensibility and specificity of new diagnostic approaches as GeneXpert, electronic nose (E-nose), infrared spectroscopy, accelerated mycobacterial growth induced by magnetism, and flow lateral devices in children populations are needed. Adequate and timely assessment of tuberculosis infection in childhood could diminish epidemiological burden because underdiagnosed pediatric patients can evolve to an active state and have the potential to disseminate the etiological agent Mycobacterium tuberculosis, notably increasing this worldwide public health problem.