Development of Vaccines against Visceral Leishmaniasis

Table 1

Vaccines against visceral leishmaniasis.

(a)

Vaccines tested against L. infantum
Antigen	Source  of  antigen	Vaccine delivery	Animal  model	Outcome	Reference
KMPII, TRYP, LACK, and GP63	L. infantum	DNA vaccine	Dog	No protection	Rodríguez-Cortés et al., 2007 [33]
H2A, H2B, H3, and H4	L. infantum	DNA vaccine	Mouse	No protection	Carrión et al., 2008 [34]
p36 LACK	L. infantum	DNA vaccine + protein expressed in vaccinia virus	Mouse	Protection	Dondji et al., 2005 [35]
p36 LACK	L. infantum	DNA vaccine	Mouse	No protection	Marques-da-Silva et al., 2005 [36]
p36 LACK	L. infantum	DNA vaccine	Mouse	Protection	Gomes et al., 2007 [37]
p36 LACK	L. infantum	DNA vaccine + protein expressed in vaccinia virus	Dog	Protection	Ramiro et al., 2003 [38]
p36 LACK	L. infantum	DNA vaccine + protein expressed in vaccinia virus	Dog	Protection	Ramos et al., 2008 [39]
CPA and CPB	L. infantum	DNA vaccine + recombinant protein	Mouse	Protection	Rafati et al., 2006 [40]
CPA and CPB	L. infantum	DNA vaccine + recombinant protein	Dog	Protection	Rafati et al., 2005 [41]
CTE of CPIII	L. infantum	DNA vaccine + recombinant protein	Mouse	No protection	Rafati et al., 2008 [42]
CPC	L. infantum	DNA vaccine + recombinant protein	Mouse	Protection	Khoshgoo et al., 2008 [43]
LCR1	L. infantum	Recombinant protein	Mouse	Partial protection	Wilson, et al., 1995 [44]
LCR1	L. infantum	Protein expressed in BCG	Mouse	Partial protection	Streit et al., 2000 [45]
PapLe22	L. infantum	DNA vaccine	Hamster	Partial protection	Fragaki et al., 2001 [46]
NH36	L. donovani	DNA vaccine	Mouse	Partial protection	Aguilar-Be et al., 2005 [47]
FML	L. donovani	Protein	Mouse	Partial protection	Aguilar-Be et al., 2005 [47]
FML	L. donovani	Protein	Mouse	Protection	Oliveira-Freitas et al., 2006 [48]
Q protein	L. infantum	Recombinant fusion protein of Lip2a, Lip2b, P0, and H2A + BCG	Dog	Protection	Molano et al., 2003 [49]
Q protein	L. infantum	Recombinant fusion protein of Lip2a, Lip2b, P0, and H2A + BCG	Mouse	Partial protection	Parody et al., 2004 [50]
A2	L. donovani	Recombinant protein	Dog	Partial protection	Fernandes et al., 2008 [51]
A2 and NH	L. donovani	DNA vaccine	Mouse	Partial protection	Zanin et al., 2007 [52]
LiESAp	L. infantum	Native protein	Dog	Protection	Lemesre et al., 2005 [53] and 2007 [54]
LiESAp	L. infantum	Native protein	Dog	Protection	Bourdoiseau et al., 2009 [29]
Leish-111f	L. major	Recombinant polyprotein of TSA, LmSTI1, and LeIF	Dog	No protection	Gradoni et al., 2005 [55]
Leish-111f	L. major	Recombinant polyprotein of TSA, LmSTI1, and LeIF formulated in MPL-SE	Dog	Protection	Coler et al., 2007 [56]
Leish-111f	L. major	Recombinant polyprotein of TSA, LmSTI1, and LeIF formulated in MPL-SE	Dog	Protection	Trigo et al., 2010 [57]

CP: cysteine proteinase; CTE: C-terminal extension; BCG: Mycobacterium bovis bacillus Calmette-Guerin; SLA: soluble leishmanial antigens; FML: fucose-mannose ligand; LiESAp: Leishmania infantum excreted-secreted antigen purified; LPG: lipophosphoglycan.

(b)

Vaccines tested against L. donovani
Antigen	Source of antigen	Vaccine delivery	Animal model	Outcome	Reference
p36 LACK	Multiple species	DNA vaccine	Mouse	No protection	Melby et al., 2001 [58]
dp72	L. donovani	Native protein antigen	Mouse	Partial protection	Jaffe et al., 1990 [59]
A2	L. donovani	Recombinant protein	Mouse	Protection	Ghosh et al., 2001 [60]
A2	L. donovani	DNA vaccine	Mouse	Protection	Ghosh et al., 2001 [61]
HASPB1	L. donovani	Recombinant protein	Mouse	Protection	Stager et al., 2000 [8]
ORFF	L. donovani	Recombinant protein	Mouse	Partial protection	Tewary et al., 2004 [62]
ORFF	L. donovani	DNA vaccine + recombinant protein	Mouse	Partial protection	Tewary et al., 2005 [63]
ORFF	L. donovani	DNA vaccine	Mouse	Partial protection	Sukumaran et al., 2003 [64]
KMP-11	L. donovani	DNA vaccine	Hamster	Protection	Basu et al., 2005 [65]
KMP-11	L. donovani	DNA vaccine	Mouse	Partial protection	Bhaumik et al., 2009 [66]
gp36	L. major	Recombinant protein expressed in bacilli	Mouse	Partial protection	McSorely et al., 1997 [67]
gp36	L. donovani	Native protein in cationic liposomes	Mouse	Partial protection	Bhowmick et al., 2008 [68]
SLA	L. donovani	Native proteins in cationic liposomes	Mouse	Protection	Bhowmick et al., 2007 [69]
SLA	L. donovani	Native proteins	Mouse	Protection	Tewary et al., 2004 [70]
LD9, LD72, LD51, LD31	L. donovani	Native proteins in cationic liposomes	Mouse	Protection	Bhowmick and Ali, 2009 [71]
Leishmanial antigens	L. donovani	Native proteins in liposomes	Mouse	Protection	Mazumdar et al., 2004 [72]
F14	L. donovani	Recombinant protein	Hamster	Partial protection	Bhardwaj et al., 2009 [73]
γ-GCS	L. donovani	DNA vaccine	Mouse	Partial protection	Carter et al., 2007 [74]
FML	L. donovani	Native protein	Mouse	Partial protection	Palanik-de-Sousa et al., 1994 [75]
FML	L. donovani	Native protein	Mouse	Partial protection	Santos et al., 1999 [76]
FML	L. donovani	Formulation with QuilA saponin	Dog	Protection	Borja-Cabrera et al., 2002 [77]
Leishmune (FML)	L. donovani	Recombinant protein	Dog	Partial protection	Saraiva et al., 2006 [78]
Leishmune (FML)	L. donovani	Recombinant protein	Dog	Protection	Nogueira et al., 2005 [79]
H2A, H2B, H3, H4 and LACK	L. donovani	Multiunit DNA vaccine	Dog	Partial protection	Saldarriaga et al., 2006 [80]
LPG	L. donovani	Purified glycolipid + BCG	Hamster and mouse	No protection	Tonui et al., 2003 [81]

CP: cysteine proteinase; CTE: C-terminal extension; BCG: Mycobacterium bovis bacillus Calmette-Guerin; SLA: soluble leishmanial antigens; FML: fucose-mannose ligand; LiESAp: Leishmania infantum excreted-secreted antigen purified; LPG: lipophosphoglycan.