Reversible Audiometric Threshold Changes in Children with Uncomplicated Malaria

Table 2

Median hearing threshold levels after 9–12 months.

Frequency	Drug	Left ear			Right ear
		Median	IQR	𝑃-value	Median	IQR	𝑃-value
125	ASAQ	22.5	20–30	0.47	20	10–25	0.03
	AML	20	16.25–25		20	16.25–25
	AQ	25	21.25–28.75		25	17.50–28.75
	CTRL	25	20–30		25	20–30
250	ASAQ	25	20–30	0.39	20	15–30	0.04
	AML	25	20–30		25	20–30
	AQ	35	27.5–35		30	15–33.75
	CTRL	25	20–30		30	20–30
500	ASAQ	25	20–30	0.78	22.5	20–30	0.10
	AML	25	20–30		25	20–30
	AQ	30	18.75–33.75		25	21.25–28.75
	CTRL	25	20–30		25	20–30
750	ASAQ	20	20–25	0.792	20	15–20	0.14
	AML	25	20–25		20	20–25
	AQ	25	17.5–28.75		25	17.5–28.75
	CTRL	25	20–30		25	20–26.25
1000	ASAQ	17.5	15–20	0.67	15	10–20	0.06
	AML	20	15–20		15	11.25–20
	AQ	20	16.25–20		20	16.25–20
	CTRL	20	15–25		20	15–25
1500	ASAQ	15	10–20	0.88	15	10–20	0.25
	AML	15	15–20		15	11.25–20
	AQ	15	15–18.75		15	11.25–18.75
	CTRL	15	13.75–20		15	15–21.25
2000	ASAQ	15	10–20	0.82	10	5–15	0.03
	AML	10	10–15		10	10–15
	AQ	15	11.25–15		10	6.25–17.50
	CTRL	15	10–20		15	10–20
3000	ASAQ	10	5–15	0.60	10	5–10	0.06
	AML	10	6.25–15		10	6.25–15
	AQ	15	11.25–15		5	5–12.5
	CTRL	15	8.75–15		10	7.5–15
4000	ASAQ	10	5–20	0.65	10	0–15	0.23
	AML	10	6.25–18.75		10	5–15
	AQ	15	3.75–15		10	10–13.75
	CTRL	10	10–16.25		10	5–15
6000	ASAQ	10	10–25	0.23	10	5–15	0.18
	AML	15	15–25		10	5–15
	AQ	15	11.25–22.5		10	10–13.75
	CTRL	15	10–20		15	10–20
8000	ASAQ	10	5–10	0.70	5	0–10	0.13
	AML	10	5–15		5	0–10
	AQ	5	1.25–16.25		10	2.5–25
	CTRL	10	5–15		10	3.75–15

ASAQ = artesunate + amodiaquine; AML: artemether-lumefantrine; AQ: amodiaquine; CTRL: control.