HLA-B*44 Is Associated with Dengue Severity Caused by DENV-3 in a Brazilian Population

Table 4

Results of two-sided Fisher’s test of association between the HLA alleles analyzed and the clinical manifestations of dengue (DHF versus DF).

HLA allele	Frequency (%)		Fisher’s test
	DF	DHF	OR (95% CI)	𝑃
B44	8.48	15.83	2.02 (0.97–4.24)	0.047
B50*	1.34	5.83	4.54 (1.01–27.72)	0.037
DR9*	3.3	0	0 (0–1.15)	0.049
DR12*	3.3	0	0 (0–1.15)	0.049
DR16*	2.36	7.14	3.17 (0.93–12.34)	0.046

HLA: human leukocyte antigen; DF: dengue fever; DHF: dengue hemorrhagic fever; OR: odds ratio; CI: confidence interval; 𝑃: 𝑃 value.
Alleles with overall allelic frequency inferior to 5% are indicated with a star.