Journal of Tropical Medicine / 2013 / Article / Tab 2

Review Article

Proteases from Entamoeba spp. and Pathogenic Free-Living Amoebae as Virulence Factors

Table 2

Enzymes from E. histolytica related species that degrade host proteins and their implication in virulence.

ParasiteTissue or proteinNameMr (kDa) Catalytic typeCommentReference

E. moshkovskii

ECM components45CPZymogram and activity of proteases secreted in azocasein[32]
 FIC strainGelatin90CPZymogram[33]
 Laredo strain Gelatin90CPZymogram[33]

E. dispar

ECM componentsEdCP330CPSequence homology with E. histolytica. Located in cytoplasmic granules[34, 35]

E. invadens

 PZ strainGelatin99, 90CPZymogram[33]
 IP101 strainGelatin99, 90, 45CPZymogram
 IP-1 strainGelatin56, 58–66, 44–54, 43CPZymogram[36]
Gelatin130–230, 55, 35CP, MPZymogram[38]
Gelatin130–230,  60CP, MPZymogram[39]