Proteases from Entamoeba spp. and Pathogenic Free-Living Amoebae as Virulence Factors

Table 2

Enzymes from E. histolytica related species that degrade host proteins and their implication in virulence.

Parasite	Tissue or protein	Name	Mr (kDa)	Catalytic type	Comment	Reference
E. moshkovskii
	ECM components	—	≈45	CP	Zymogram and activity of proteases secreted in azocasein	[32]
FIC strain	Gelatin	—	90	CP	Zymogram	[33]
Laredo strain	Gelatin	—	90	CP	Zymogram	[33]
E. dispar
	ECM components	EdCP3	≈30	CP	Sequence homology with E. histolytica. Located in cytoplasmic granules	[34, 35]
E. invadens
PZ strain	Gelatin		99, 90	CP	Zymogram	[33]
IP101 strain	Gelatin		99, 90, 45	CP	Zymogram	[33]
IP-1 strain	Gelatin		56, 58–66, 44–54, 43	CP	Zymogram	[36]
	Gelatin		45	SP	Zymogram	[37]
	Gelatin		130–230, 55, 35	CP, MP	Zymogram	[38]
	Gelatin		130–230,  60	CP, MP	Zymogram	[39]
	Azocasein		28	CP	Zymogram	[40]