Early Treatment with Intranasal Neostigmine Reduces Mortality in a Mouse Model of Naja naja (Indian Cobra) Envenomation

Table 1

Survival times for all venom dosages compared with and without IN neostigmine treatment. 𝑃 values shown were as calculated by nonparametric Mann-Whitney test.

Treatment	Mean survival time in minutes (range)	𝑃 value	Number of mice per group
2.5× LD50 venom	193 (67–332)	<0.02	5
2.5× LD50 + neostigmine	553 (144–720)		15
5× LD50	45 (40–48)	=0.01	5
5× LD50 + neostigmine	196 (50–720)		5
10× LD50	30 (25–35)	<0.02	5
10× LD50 + neostigmine	175 (35–720)		5