Molecular Epidemiology and Genetic Diversity of Norovirus in Young Children in Phnom Penh, Cambodia

Table 2

Summary of nonrecombinant (a) and recombinant (b) norovirus genotypes detected in case and control samples based on the Norovirus Genotyping Tool and phylogenetic analysis and Simplot for recombination analysis.

(a)

Genotypes		Number of samples
ORF1	ORF2	Case	Control
GI.P8	GI.8	1	0
GII.P2	GII.2	1	0
GII.P3	GII.3	2	0
GII.P4	GII.4 Asia 2003	2	1
GII.P12	GII.4 Asia 2003	3	1
GII.P4	GII.4 Hunter 2004	5	2
GII.P4	GII.4 Yerseke 2006a	3	0
GII.P6	GII.6	1	0
GII.P12	GII.12	2	0
GII.P16	GII.16	1	3

(b)

Recombinants
Genotypes		Number of samples		Recombination position	Lordsdale nucleotide position	First report
ORF1	ORF2	Case	Control
GI.Pc	GI.5	1	0	—	—	Japan 1997–2001 [21]
GII.P7	GII.6	5	1	101–128	5022–5049	Burkina Faso 2011 [22]
GII.P7	GII.14	3	0	—	—	China [23]
GII.P7	GII.20	3	0	97–	5022-5034	Brazil 2008 [24]
GII.P12	GII.13	1	0	144–152	5065–5073	South Korea 2004–2007 [25]
GII.P16	GII.17	1	0	191–201	5112–5122	South Africa 2010–2012 [26]
GII.P21	GII.3	1	0	147–156	5067–5076	Europe, Australia, Japan, 2002-2003 [10, 27, 28]

Recombination breakpoint positions of each genotype and corresponding positions in the reference strain Lordsdale are reported.
⁢ based on NP-492_2.
⁢ original publication described the recombinant as GII.P6/GII.14 (GenBank accession number EF670650) but the Norovirus Genotyping Tool and phylogenetic analysis showed that it was closely related to GII.P7/GII.14.