Journal of Tropical Medicine / 2016 / Article / Tab 3

Review Article

Antibacterial Action of Curcumin against Staphylococcus aureus: A Brief Review

Table 3

Challenges of curcumin use in clinical setting.

ChallengeReferences

Cytotoxicity
DNA damage and chromosome aberrations[5053]
Carcinogenesis
Promote tumour formation in vivo[54, 55]
Iron chelation
Alter systemic iron metabolism[56]
Enzyme inhibition
Inhibit drug-metabolizing enzymes[57, 58]
Solubility
Hydrophobic nature does not support water solubility[59, 60]
Bioavailability
Degradation by plasma protease and nonspecific protein binding[26, 27, 61, 62]