Antimalarial Properties of Aqueous Crude Extracts of Gynostemma pentaphyllum and Moringa oleifera Leaves in Combination with Artesunate in Plasmodium berghei-Infected Mice

Figure 1

Antimalarial activity of Gynostemma pentaphyllum. Groups of naïve ICR mice (5 mice each) were infected intraperitoneally with 1 × 10⁷ parasitized erythrocytes of PbANKA. They were then given orally the extract (500, 1,000, and 2,000 mg/kg) either alone or in combination with artesunate (6 mg/kg) for 4 consecutive days. Untreated and artesunate treated mice were used as negative and positive controls, respectively. Parasitemia and suppression percentage were subsequently measured. , and , compared to untreated control. UN: untreated control; GPE: G. pentaphyllum extract; ART: 6 mg/kg of artesunate; A + 500: combination of 6 mg/kg of artesunate and 500 mg/kg of GPE; A + 1000: combination of 6 mg/kg of artesunate and 1000 mg/kg of GPE; A + 2000: combination of 6 mg/kg of artesunate and 2000 mg/kg of GPE. The results came from 3 independent experiments.