Research Article

Qualitative and Quantitative Microbiological Studies of Paediatric Artemether-Lumefantrine Dry Powders and Paracetamol Syrups Obtained from Selected Drug Stores in Accra, Ghana

Table 2

Results of the microbiological analyses of artemether-lumefantrine dry powder and paracetamol syrup.

BrandSample No.Artemether-lumefantrine Dry PowderParacetamol Syrup
Microbial CountPathogensMicrobial CountPathogens
TAMCTYMCE. coliSalmonella spp.P. aeruginosaS. aureusTAMCTYMCE. coliSalmonella spp.P. aeruginosaS. aureus
(cfu/g)(cfu/g)(cfu/mL)(cfu/mL)

A12.0 x 101< 10NDNDNDND< 10< 10NDNDNDND
2< 10< 10NDNDNDND< 10< 10NDNDNDND
3< 10< 10NDNDNDND< 10< 10NDNDNDND
4< 10< 10NDNDNDND< 10< 10NDNDNDND
5< 10< 10NDNDNDND2.0 x 101< 10NDNDNDND
61.5 x 101< 10NDNDNDND< 10< 10NDNDNDND
71.0 x 1011.5 x 101NDNDNDND< 10< 10NDNDNDND
81.0 x 101< 10NDNDNDND< 101.0 x 101NDNDNDND
9< 10< 10NDNDNDND< 10< 10NDNDNDND
101.0 x 101< 10NDNDNDND< 10< 10NDNDNDND

B17.5 x 101< 10NDNDNDND4.3 x 1021.25 x 102NDNDNDND
23.0 x 1012.5 x 101NDNDNDND4.15 x 1029.5 x 101NDNDNDND
32.5 x 101< 10NDNDNDND2.7 x 1021.15 x 102NDNDNDND
44.0 x 1015.5 x 101NDNDPresentND2.85 x 1028.5 x 101NDPresentNDND
56.0 x 101< 10NDNDNDND< 10< 10NDNDNDND
61.5 x 101< 10NDNDNDND5.05 x 1028.5 x 101NDNDNDND
78.0 x 101< 10NDNDPresentND4.36 x 1028.85 x 102NDNDNDND
82.0 x 1016.5 x 101NDNDPresentND3.85 x 1027.5 x 101NDNDNDND
93.0 x 1015.5 x 101NDNDNDND2.0 x 101< 10NDNDNDND
107.5 x 1012.0 x 101NDNDNDND1.0 x 101< 10NDNDNDND

C1< 10< 10NDNDNDND2.5 x 1011.5 x 101NDNDNDND
2< 10< 10NDNDNDND< 10< 10NDNDPresentND
31.0 x 101< 10NDNDNDND< 10< 10NDNDNDND
41.0 x 101< 10NDNDNDND1.5 x 101< 10NDNDNDND
5< 10< 10NDNDNDND1.9 x 1021.1 x 102NDNDNDND
6< 10< 10NDNDNDND2.5 x 1011.5 x 101NDNDNDND
71.5 x 101< 10NDNDNDND1.0 x 101< 10NDNDNDND
8< 101.0 x 101NDNDNDND< 10< 10NDNDNDND
92.5 x 101< 10NDNDNDND< 10< 10NDNDNDND
10< 10< 10NDNDNDND< 10< 10NDNDNDND

D12.5 x 101< 10NDNDNDND1.4 x 1021.25 x 102NDNDNDND
21.5 x 1011.5 x 101NDNDNDND3.5 x 1011.5 x 101NDNDNDND
31.5 x 1011.0 x 101NDNDNDND3.5 x 101< 10NDNDNDND
41.5 x 101< 10NDNDNDND2.0 x 101< 10NDNDNDND
51.5 x 1012.5 x 101NDNDNDND< 10< 10NDNDNDND
64.0 x 1011.0 x 101NDNDNDND< 10< 10NDNDNDND
7< 10< 10NDNDNDND1.0 x 101< 10NDNDNDND
82.0 x 1012.5 x 101NDNDNDND< 10< 10NDNDNDND
91.0 x 101< 10NDNDNDND2.7 x 1023.0 x 101NDNDNDND
101.0 x 101< 10NDNDNDND< 10< 10NDNDNDND

E15.5 x 1011.5 x 101NDNDNDND9.5 x 1013.0 x 101NDNDNDND
24.0 x 101< 10NDNDNDND< 10< 10NDNDNDND
31.5 x 101< 10NDNDNDND2.5 x 1024.0 x 101NDNDNDND
42.0 x 1012.5 x 101NDNDNDND2.0 x 1011.0 x 101NDNDNDND
51.0 x 101< 10NDNDNDND9.5 x 1011.5 x 101NDNDNDND
62.0 x 101< 10NDNDNDND1.0 x 101< 10NDNDNDND
7< 102.0 x 101NDNDNDND< 10< 10NDNDNDND
85.5 x 101< 10NDNDNDND< 10< 10NDNDNDND
9< 102.5 x 101NDNDNDND9.5 x 1011.5 x 101NDNDNDND
101.5 x 1013.5 x 101NDNDNDND2.5 x 101< 10NDNDNDND

F11.0 x 101< 10NDNDNDND1.65 x 102< 10NDNDNDND
21.0 x 101< 10NDNDNDND< 10< 10NDNDNDND
32.0 x 101< 10NDNDNDND3.0 x 1011.5 x 101NDNDNDND
49.5 x 101< 10NDNDPresentND< 10< 10NDPresentNDND
5< 101.0 x 101NDNDNDND1.0 x 101< 10NDNDNDND
6< 10< 10NDNDNDND1.0 x 101< 10NDNDNDND
73.5 x 1011.0 x 101NDNDNDND< 10< 10NDNDNDND
83.5 x 101< 10NDNDNDND< 10< 10NDNDNDND
91.0 x 101< 10NDNDNDND5.15 x 1021.85 x 102NDNDPresentND
101.5 x 101< 10NDNDNDND< 10< 10NDNDNDND

G11.0 x 101< 10NDNDNDND1.75 x 1021.10 x 102NDNDNDND
21.5 x 101< 10NDNDNDND1.0 x 1011.0 x 101NDNDNDND
31.5 x 101< 10NDNDNDND< 10< 10NDNDNDND
4< 102.0 x 101NDNDNDND2.5 x 101< 10NDNDNDND
52.0 x 101< 10NDNDNDND2.65 x 102< 10NDNDNDND
62.0 x 101< 10NDNDNDND2.0 x 1011.0 x 101NDNDNDND
7< 104.0 x 101NDNDNDND< 10< 10NDNDNDND
81.5 x 1011.5 x 101NDNDNDND< 10< 10NDNDNDND
91.5 x 1012.5 x 101NDNDNDND2.0 x 101< 10NDNDNDND
101.5 x 101< 10NDNDNDND1.5 x 101< 10NDNDNDND

H11.5 x 1012.0 x 101NDNDNDND< 10< 10NDNDNDND
21.5 x 1013.5 x 101NDNDNDND< 10< 10NDNDNDND
32.5 x 1014.0 x 101NDNDNDND< 10< 10NDPresentPresentND
41.0 x 101< 10NDNDNDND< 10< 10NDNDNDND
51.0 x 101< 10NDNDNDND< 10< 10NDPresentNDND
63.0 x 1012.5 x 101NDNDNDND9.5 x 1013.0 x 101NDNDNDND
7< 10< 10NDNDNDND1.60 x 1021.05 x 102NDNDNDND
82.0 x 101< 10NDNDNDND1.0 x 1011.0 x 101NDNDNDND
92.0 x 101< 10NDNDNDND< 10< 10NDNDPresentND
101.0 x 1013.0 x 101NDNDNDND< 10< 10NDNDNDND

I11.5 x 101< 10NDNDNDND< 10< 10NDNDNDND
21.5 x 101< 10NDNDNDND< 10< 10NDNDNDND
32.0 x 101< 10NDNDNDND< 10< 10NDNDNDND
42.5 x 1012.0 x 101NDNDNDND1.5 x 101< 10NDNDNDND
51.5 x 1011.0 x 101NDNDNDND3.5 x 1011.5 x 101NDNDNDND
6< 10< 10NDNDNDND3.0 x 1011.5 x 101NDNDNDND
7< 101.0 x 101NDNDNDND< 10< 10NDNDNDND
8< 10< 10NDNDNDND3.5 x 101< 10NDNDNDND
95.0 x 101< 10NDNDNDND< 10< 10NDPresentNDND
101.5 x 1011.5 x 101NDNDNDND1.0 x 101< 10NDNDNDND

TAMC: Total Aerobic Microbial Count, TYMC: Total Yeasts and Moulds Count, cfu: colony-forming units, ND: not detected.