Qualitative and Quantitative Microbiological Studies of Paediatric Artemether-Lumefantrine Dry Powders and Paracetamol Syrups Obtained from Selected Drug Stores in Accra, Ghana
Table 2
Results of the microbiological analyses of artemether-lumefantrine dry powder and paracetamol syrup.
Brand
Sample No.
Artemether-lumefantrine Dry Powder
Paracetamol Syrup
Microbial Count
Pathogens
Microbial Count
Pathogens
TAMC
TYMC
E. coli
Salmonella spp.
P. aeruginosa
S. aureus
TAMC
TYMC
E. coli
Salmonella spp.
P. aeruginosa
S. aureus
(cfu/g)
(cfu/g)
(cfu/mL)
(cfu/mL)
A
1
2.0 x 101
< 10
ND
ND
ND
ND
< 10
< 10
ND
ND
ND
ND
2
< 10
< 10
ND
ND
ND
ND
< 10
< 10
ND
ND
ND
ND
3
< 10
< 10
ND
ND
ND
ND
< 10
< 10
ND
ND
ND
ND
4
< 10
< 10
ND
ND
ND
ND
< 10
< 10
ND
ND
ND
ND
5
< 10
< 10
ND
ND
ND
ND
2.0 x 101
< 10
ND
ND
ND
ND
6
1.5 x 101
< 10
ND
ND
ND
ND
< 10
< 10
ND
ND
ND
ND
7
1.0 x 101
1.5 x 101
ND
ND
ND
ND
< 10
< 10
ND
ND
ND
ND
8
1.0 x 101
< 10
ND
ND
ND
ND
< 10
1.0 x 101
ND
ND
ND
ND
9
< 10
< 10
ND
ND
ND
ND
< 10
< 10
ND
ND
ND
ND
10
1.0 x 101
< 10
ND
ND
ND
ND
< 10
< 10
ND
ND
ND
ND
B
1
7.5 x 101
< 10
ND
ND
ND
ND
4.3 x 102
1.25 x 102
ND
ND
ND
ND
2
3.0 x 101
2.5 x 101
ND
ND
ND
ND
4.15 x 102
9.5 x 101
ND
ND
ND
ND
3
2.5 x 101
< 10
ND
ND
ND
ND
2.7 x 102
1.15 x 102
ND
ND
ND
ND
4
4.0 x 101
5.5 x 101
ND
ND
Present
ND
2.85 x 102
8.5 x 101
ND
Present
ND
ND
5
6.0 x 101
< 10
ND
ND
ND
ND
< 10
< 10
ND
ND
ND
ND
6
1.5 x 101
< 10
ND
ND
ND
ND
5.05 x 102
8.5 x 101
ND
ND
ND
ND
7
8.0 x 101
< 10
ND
ND
Present
ND
4.36 x 102
8.85 x 102
ND
ND
ND
ND
8
2.0 x 101
6.5 x 101
ND
ND
Present
ND
3.85 x 102
7.5 x 101
ND
ND
ND
ND
9
3.0 x 101
5.5 x 101
ND
ND
ND
ND
2.0 x 101
< 10
ND
ND
ND
ND
10
7.5 x 101
2.0 x 101
ND
ND
ND
ND
1.0 x 101
< 10
ND
ND
ND
ND
C
1
< 10
< 10
ND
ND
ND
ND
2.5 x 101
1.5 x 101
ND
ND
ND
ND
2
< 10
< 10
ND
ND
ND
ND
< 10
< 10
ND
ND
Present
ND
3
1.0 x 101
< 10
ND
ND
ND
ND
< 10
< 10
ND
ND
ND
ND
4
1.0 x 101
< 10
ND
ND
ND
ND
1.5 x 101
< 10
ND
ND
ND
ND
5
< 10
< 10
ND
ND
ND
ND
1.9 x 102
1.1 x 102
ND
ND
ND
ND
6
< 10
< 10
ND
ND
ND
ND
2.5 x 101
1.5 x 101
ND
ND
ND
ND
7
1.5 x 101
< 10
ND
ND
ND
ND
1.0 x 101
< 10
ND
ND
ND
ND
8
< 10
1.0 x 101
ND
ND
ND
ND
< 10
< 10
ND
ND
ND
ND
9
2.5 x 101
< 10
ND
ND
ND
ND
< 10
< 10
ND
ND
ND
ND
10
< 10
< 10
ND
ND
ND
ND
< 10
< 10
ND
ND
ND
ND
D
1
2.5 x 101
< 10
ND
ND
ND
ND
1.4 x 102
1.25 x 102
ND
ND
ND
ND
2
1.5 x 101
1.5 x 101
ND
ND
ND
ND
3.5 x 101
1.5 x 101
ND
ND
ND
ND
3
1.5 x 101
1.0 x 101
ND
ND
ND
ND
3.5 x 101
< 10
ND
ND
ND
ND
4
1.5 x 101
< 10
ND
ND
ND
ND
2.0 x 101
< 10
ND
ND
ND
ND
5
1.5 x 101
2.5 x 101
ND
ND
ND
ND
< 10
< 10
ND
ND
ND
ND
6
4.0 x 101
1.0 x 101
ND
ND
ND
ND
< 10
< 10
ND
ND
ND
ND
7
< 10
< 10
ND
ND
ND
ND
1.0 x 101
< 10
ND
ND
ND
ND
8
2.0 x 101
2.5 x 101
ND
ND
ND
ND
< 10
< 10
ND
ND
ND
ND
9
1.0 x 101
< 10
ND
ND
ND
ND
2.7 x 102
3.0 x 101
ND
ND
ND
ND
10
1.0 x 101
< 10
ND
ND
ND
ND
< 10
< 10
ND
ND
ND
ND
E
1
5.5 x 101
1.5 x 101
ND
ND
ND
ND
9.5 x 101
3.0 x 101
ND
ND
ND
ND
2
4.0 x 101
< 10
ND
ND
ND
ND
< 10
< 10
ND
ND
ND
ND
3
1.5 x 101
< 10
ND
ND
ND
ND
2.5 x 102
4.0 x 101
ND
ND
ND
ND
4
2.0 x 101
2.5 x 101
ND
ND
ND
ND
2.0 x 101
1.0 x 101
ND
ND
ND
ND
5
1.0 x 101
< 10
ND
ND
ND
ND
9.5 x 101
1.5 x 101
ND
ND
ND
ND
6
2.0 x 101
< 10
ND
ND
ND
ND
1.0 x 101
< 10
ND
ND
ND
ND
7
< 10
2.0 x 101
ND
ND
ND
ND
< 10
< 10
ND
ND
ND
ND
8
5.5 x 101
< 10
ND
ND
ND
ND
< 10
< 10
ND
ND
ND
ND
9
< 10
2.5 x 101
ND
ND
ND
ND
9.5 x 101
1.5 x 101
ND
ND
ND
ND
10
1.5 x 101
3.5 x 101
ND
ND
ND
ND
2.5 x 101
< 10
ND
ND
ND
ND
F
1
1.0 x 101
< 10
ND
ND
ND
ND
1.65 x 102
< 10
ND
ND
ND
ND
2
1.0 x 101
< 10
ND
ND
ND
ND
< 10
< 10
ND
ND
ND
ND
3
2.0 x 101
< 10
ND
ND
ND
ND
3.0 x 101
1.5 x 101
ND
ND
ND
ND
4
9.5 x 101
< 10
ND
ND
Present
ND
< 10
< 10
ND
Present
ND
ND
5
< 10
1.0 x 101
ND
ND
ND
ND
1.0 x 101
< 10
ND
ND
ND
ND
6
< 10
< 10
ND
ND
ND
ND
1.0 x 101
< 10
ND
ND
ND
ND
7
3.5 x 101
1.0 x 101
ND
ND
ND
ND
< 10
< 10
ND
ND
ND
ND
8
3.5 x 101
< 10
ND
ND
ND
ND
< 10
< 10
ND
ND
ND
ND
9
1.0 x 101
< 10
ND
ND
ND
ND
5.15 x 102
1.85 x 102
ND
ND
Present
ND
10
1.5 x 101
< 10
ND
ND
ND
ND
< 10
< 10
ND
ND
ND
ND
G
1
1.0 x 101
< 10
ND
ND
ND
ND
1.75 x 102
1.10 x 102
ND
ND
ND
ND
2
1.5 x 101
< 10
ND
ND
ND
ND
1.0 x 101
1.0 x 101
ND
ND
ND
ND
3
1.5 x 101
< 10
ND
ND
ND
ND
< 10
< 10
ND
ND
ND
ND
4
< 10
2.0 x 101
ND
ND
ND
ND
2.5 x 101
< 10
ND
ND
ND
ND
5
2.0 x 101
< 10
ND
ND
ND
ND
2.65 x 102
< 10
ND
ND
ND
ND
6
2.0 x 101
< 10
ND
ND
ND
ND
2.0 x 101
1.0 x 101
ND
ND
ND
ND
7
< 10
4.0 x 101
ND
ND
ND
ND
< 10
< 10
ND
ND
ND
ND
8
1.5 x 101
1.5 x 101
ND
ND
ND
ND
< 10
< 10
ND
ND
ND
ND
9
1.5 x 101
2.5 x 101
ND
ND
ND
ND
2.0 x 101
< 10
ND
ND
ND
ND
10
1.5 x 101
< 10
ND
ND
ND
ND
1.5 x 101
< 10
ND
ND
ND
ND
H
1
1.5 x 101
2.0 x 101
ND
ND
ND
ND
< 10
< 10
ND
ND
ND
ND
2
1.5 x 101
3.5 x 101
ND
ND
ND
ND
< 10
< 10
ND
ND
ND
ND
3
2.5 x 101
4.0 x 101
ND
ND
ND
ND
< 10
< 10
ND
Present
Present
ND
4
1.0 x 101
< 10
ND
ND
ND
ND
< 10
< 10
ND
ND
ND
ND
5
1.0 x 101
< 10
ND
ND
ND
ND
< 10
< 10
ND
Present
ND
ND
6
3.0 x 101
2.5 x 101
ND
ND
ND
ND
9.5 x 101
3.0 x 101
ND
ND
ND
ND
7
< 10
< 10
ND
ND
ND
ND
1.60 x 102
1.05 x 102
ND
ND
ND
ND
8
2.0 x 101
< 10
ND
ND
ND
ND
1.0 x 101
1.0 x 101
ND
ND
ND
ND
9
2.0 x 101
< 10
ND
ND
ND
ND
< 10
< 10
ND
ND
Present
ND
10
1.0 x 101
3.0 x 101
ND
ND
ND
ND
< 10
< 10
ND
ND
ND
ND
I
1
1.5 x 101
< 10
ND
ND
ND
ND
< 10
< 10
ND
ND
ND
ND
2
1.5 x 101
< 10
ND
ND
ND
ND
< 10
< 10
ND
ND
ND
ND
3
2.0 x 101
< 10
ND
ND
ND
ND
< 10
< 10
ND
ND
ND
ND
4
2.5 x 101
2.0 x 101
ND
ND
ND
ND
1.5 x 101
< 10
ND
ND
ND
ND
5
1.5 x 101
1.0 x 101
ND
ND
ND
ND
3.5 x 101
1.5 x 101
ND
ND
ND
ND
6
< 10
< 10
ND
ND
ND
ND
3.0 x 101
1.5 x 101
ND
ND
ND
ND
7
< 10
1.0 x 101
ND
ND
ND
ND
< 10
< 10
ND
ND
ND
ND
8
< 10
< 10
ND
ND
ND
ND
3.5 x 101
< 10
ND
ND
ND
ND
9
5.0 x 101
< 10
ND
ND
ND
ND
< 10
< 10
ND
Present
ND
ND
10
1.5 x 101
1.5 x 101
ND
ND
ND
ND
1.0 x 101
< 10
ND
ND
ND
ND
TAMC: Total Aerobic Microbial Count, TYMC: Total Yeasts and Moulds Count, cfu: colony-forming units, ND: not detected.