Research Article

Chemical Synthesis, Efficacy, and Safety of Antimalarial Hybrid Drug Comprising of Sarcosine and Aniline Pharmacophores as Scaffolds

Table 1

IC50 of sarcosine-aniline hybrid versus control drugs on P. falciparum 3D7 strains.

DrugsIC50 value
1234

1Sarcosine-aniline hybrid drug44.80 ± 4.70 ng/ml
2Aniline22.86 ± 1.26 ng/ml
3Artesunate2.63 ± 0.38 ng/ml0.46
4Chloroquine5.69 ± 0.39 ng/ml0.46
5SarcosineNo activity

Significant: . In this table, 1: sarcosine-aniline hybrid drug, 2: aniline, 3: artesunate, 4: chloroquine, and 5: sarcosine.