Efficacy of Praziquantel for the Treatment of Human Schistosomiasis in Ethiopia: A Systematic Review and Meta-Analysis

Table 1

Summary of the characteristics of eligible studies included in this meta-analysis for evaluating praziquantel drugs used for the treatment of human schistosomiasis in Ethiopia.

Author, year	Study area (s)	Region	Participants	Age (years)	Schistosome species	Diagnostic approach	Follow-up time	Total population	Cured/treated	Cure rate (%) (95% CI)	ERR (%)
Taddese and Zein, 1988	Wonji	Oromia	Patients	17–52	S. mansoni	Kato-Katz	4 weeks	200	47/49	96 (86.0–99.5)	90
Birrie et al., 1993	Addis Ababa	Addis Ababa	Community based	20–34	S. haematobium	N/A	6 weeks	50	50/50	100 (92.9–100)	N/A
Yencneh et al., 1996	Jiga	Amhara	Community based	>5	S. mansoni	Kato-Katz	8 weeks	4861	596/670	89 (86.5–91.3)	N/A
Berhe et al., 1999	Bati, Harbu, and Kemise	Amhara	Schoolchildren	5–17	S. mansoni	Kato-Katz	5 weeks	611	450/541	83.2 (80–86.3)	N/A
Degu et al., 2002	Gorgora	Amhara	Schoolchildren	10–14	S. mansoni	Kato-Katz	6 weeks	325	148/154	94 (93.0–99.1)	97
Dejenie et al., 2010	Tumuga and Waja	Tigray	Schoolchildren	5–19	S. mansoni	Kato-Katz	4 weeks	390	205/225	91.1 (87.4–94.8)	N/A
Reta and Erko, 2010	Senbete Town	Amhara	Schoolchildren	10.81	S. mansoni	Kato-Katz	4 weeks	342	155/187	82.9 (77.5–88.3)	79.5
Erko et al., 2012	Wondo Genet	SNNP	Schoolchildren	6–22	S. mansoni	Kato-Katz	4 weeks	299	106/144	73.6 (65.9 –80.1)	68.2
Haile et al., 2012	Finchaa Valley	Oromia	Schoolchildren	6–14	S. mansoni	Kato-Katz	4 weeks	324	165/204	80.9 (75.5–86.3)	99.5
Mekonnen et al., 2013	Blue Nile Vally	Amhara	Community based	2–60	S. haematobium	Urine filtration	7 weeks	341	132/152	86.8 (81.5–92.2)	85
Bajiro et al., 2016	Mana district	Oromia	Schoolchildren	6–18	S. mansoni	Kato-Katz	3weeks	500	114/115	99.1 (95.2–99.9)	99.9
Hailu et al., 2018	Bahir Dar	Amhara	Schoolchildren	6–14	S. mansoni	FECT	2 weeks	409	49/53	92.4 (85.3–99.5)	N/A
Kemal et al., 2019	Erer Health Center	Somali	Preschool children	<6	S. mansoni	Kato-Katz	4 weeks	236	57/59	96.4 (88.3–99.5)	99.4
Woldegerima et al., 2019	Sanja Town	Amhara	Schoolchildren	9–14	S. mansoni	Kato-Katz	3 weeks	372	72/80	90 (83.4–96.5)	99.6
Tesfie et al., 2020	Sanja Town	Amhara	Schoolchildren	6–18	S. mansoni	Kato-Katz	4 weeks	245	153/176	86.9(81.0–91.5)	78.3