TSH Isoforms: About a Case of Hypothyroidism in a Down's Syndrome Young Adult

Table 1

Control of initial thyroid parameters TSH, FT3, and FT4 by different assays and additional biological parameters.

	Patient’s results	Reference values
TSH	1392^1	0.25–4 mIU/L
	1200^2	0.27–4.2 mIU/L
	1540^3*	0.29–3.8 mIU/L
FT4	0.66^4	8.2–18 pmol/L
	1.6^5	11.5–23 pmol/L
	1.3^5*	13–22.6 pmol/L
FT3	1.14^4	4.2–8.3 pmol/L
	1.7^5	2.5–5.8 pmol/L
	1.9^5*	2.8–5.3 pmol/L
Anti-thyroid peroxidase antibodies (AbTPO)^6	4047	$<$60 kU/L
Thyroglobulin (Tg)^1	< 0.7	$<$50 $\mu$g/L
Anti-thyroglobulin antibodies (AbTg)^6	198	$<$60 kU/L
Anti-TSH receptor antibodies (TSHR)^6	216	$<$1.0 U/L
Blocking anti-TSHR^7	81	$<$10%
Stimulating anti-TSHR^7	243	100%
Anti-T3 antibodies^7	4.9	$<$7.9%
Anti-T4 antibodies^7	3.7	$<$7%
Anti-TSH antibodies^7	13	$<$18%
Total cholesterol^8	9.3	4.5–6.0 mmol/L
Total Testosterone^1	11.3	8.2–34.6 nmol/L
Alpha-subunits^3	2.8	$<$0.8 IU/L
Prolactin^3	1009	30–545 mIU/L
Luteinizing hormone (LH)^3	4.6	1.8–8.4 IU/L
Follicle-stimulating hormone (FSH)^3	18.3	2.2–10 IU/L
Radioelectrophoresis:
(i) Thyroxin-Binding Protein	69.7	63.6–81.2%
(ii) Albumin	6.0	2.9–9.7%
(iii) Transthyretin	23.8	12.5–29.7%
(iv) Immunoglobulins	0.5	$<$2.0%

¹CisBio, ²Modular Roche Diagnostic, ³ IRMA Beckman Coulter, ⁴RIA lisophase Cis Bio, ⁵RIA Beckman Coulter, ⁶Brahms, ⁷in-house assay, Biological Center Lyon Sud, ⁸ Olympus. ${}^{\mathit{*}}$Pretreatment with “Heterophilic Blocking Tube’’ scantibodies.