Journal of Thyroid Research / 2010 / Article / Tab 1

Case Report

Plasma Cell Granuloma of the Thyroid: A Conservative Approach to a Rare Condition and Review of the Literature

Table 1

Clinical and pathological features of reported cases of plasma cell granuloma of the thyroid.

PaperAge/SexPresentationThyroid functionAutoimmunityPathologyTreatment

Chan et al. 1986 [15]35 FNeck lump, right lobe nodule. Mild tracheal compressionEuthyroidNo3 cm white, round nodule. Plasma cell aggregates. Hurtle cells absent. Polyclonal pattern on stainingRight hemithyroidectomy
De Mascarel et al. 1989 [16]35 F3 cm nodule in left lobeEuthyroidNo2.2 cm firm lesion. Fibrous tissue with polyclonal plasma cellsThyroidectomy
Ferrer-Garcia et al. 2004 [11]41 MGoiterHypothyroidHashimoto’s Polyclonal plasma cells with evidence of Hashimoto’s thyroiditis. FNA inconclusive. Total thyroidectomy
Fontenot et al. 2008 [17]55 FEnlarging neck swelling, with compressive symptomsHypothyroidNoFirm, fibrotic lesion. Polyclonal plasma cells with the expression of both kappa and lambda light chainsThyroidectomy
Holck, 1981 [18]70 FNeck swelling with breathing difficulties. Right lobe, 3 cm nodule on examinationHypothyroidNoObliteration of parenchyma with mature plasma cells. No Hurtle cell changesSubtotal thyroidectomy
Kojima et al. 2009 [19]75 FPainless left-sided neck swellingEuthyroidNoInflammatory pseudotumour (IPT). Predominantly fibrohistiocytic. Vimentin and CD68 +ve.Lobectomy
Kriegl et al. 2007 [12]50 MThyroid enlargement with dysphagiaEuthyroidHashimoto’sPolyclonal plasma cells with associated Hashimoto’s thyroiditis. EBV and HHV8 DNA negative.Subtotal thyroidectomy
Laurent et al. 2004 [13]35 FDysphagia and asthenia. Normal thyroid on examination. Later painful enlargement of thyroid with signs of tracheal compressionHypothyroid?Hashimoto’s ( antimicrosomal antibodies, anti-TPO positive)Numerous plasma cells, macrophages and T lymphocytes and B lymphocytes. Plasma cells polyclonalMethylprednisolone initially without response. Unable to excise due to fibrosis, biopsy taken. IV methylprednisolone given followed by IV cyclophosphamide and oral azathioprine for 6 months
Li Voon Chong et al. 2001 [20]29 MNeck tenderness, dysphagia, odynophagia, and fever. 8 cm mass in left lobe. EuthyroidDiabetes MellitusHistology proven plasma cell granuloma. Staining showed presence of IgG, IgM, and IgA.Initial antibiotics. Surgical exploration with multiple biopsies
Martinez et al. 2002 [8]46 FLarge painless neck mass. History of goitre. EuthyroidNo3 to 15 mm nodules separated by fibrous bundles. Numerous plasma cells with Hurtle cell changesTotal thyroidectomy
Mugler et al. 2003 [14]46 MPainless left neck mass. Family history of thyroid Ca. Dominant nodule on examinationHypothroidHashimoto’s5×3×3 cm nodule. Changes consistent with thyroiditis, including Hurtle cell changes. Plasma cell aggregation, polyclonal on staining.Neoplasm could not be ruled out on FNA. Total thyroidectomy
Talmi et al. 1989 [21]51 FPainless enlarging nodule in right lobe. Not knownNo2 cm white nodule. Mature polyclonal plasma cells.Lobectomy
Yapp et al. 1985 [9]61 FPainless goiter enlargement. HypothyroidNoPolyclonal plasma cells. Hurtle cell changes. Some lymph node enlargementTotal thyroidectomy
Zingrillo et al. 1995 [10]65 FNeck swelling and breathing difficulties. 3×5 cm nodule in left lobeHypothyroidHashimoto’sPolyclonal plasma cells with lymphocytic infiltrate. Hurtle cell changes presentTotal thyroidectomy

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