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Journal of Thyroid Research
Volume 2011, Article ID 194721, 5 pages
Research Article

Hyperthyroidism-Associated Insulin Resistance Is Not Mediated by Adiponectin Levels

1Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Veterans General Hospital, 386, Ta-Chung 1st Road, Kaohsiung 813, Taiwan
2Department of Rehabilitation Technology, TzuHui Institute of Technology, 367, San Min Road, Nanchou, Pingtung 926, Taiwan
3School of Medicine, National Yang-Ming University, 155, Sec. 2, Li-Nong Street, Pei-Tou, Taipei 112, Taiwan

Received 8 September 2010; Revised 30 November 2010; Accepted 19 December 2010

Academic Editor: Gabriela Brenta

Copyright © 2011 Chih-Hsun Chu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


To evaluate the relationship between circulating adiponectin and insulin sensitivity in patients with hyperthyroid Graves' disease, we studied 19 adult patients with this disease and 19 age- and sex-matched euthyroid controls. All hyperthyroid patients were treated with antithyroid drugs and were re-evaluated after thyroid function normalized. Before antithyroid treatment, the adiponectin plasma concentrations were not different comparing with those in control group. The adiponectin levels remained unchanged after treatment. The homeostasis model assessment of insulin resistance (HOMA-IR) in hyperthyroid group was higher before treatment than after treatment. There was no significant difference in serum glucose and insulin levels between hyperthyroid and control groups and in the hyperthyroid group before and after treatment. BMI-adjusted adiponectin levels were not different among three groups. On the other hand, BMI-adjusted insulin levels and HOMA-IR values were significantly decreased after management of hyperthyroidism. Pearson's correlation revealed that insulin and HOMA-IR values positively correlated with triiodothyronine (T3) and free thyroxine (FT4) levels. However, adiponectin did not correlate with T3, FT4, insulin, HOMA-IR and thyrotropin receptor autoantibody (TRAb) levels. In conclusion, insulin resistance associated with hyperthyroidism is not mediated by the levels of plasma adiponectin.