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Journal of Thyroid Research
Volume 2011, Article ID 235130, 5 pages
http://dx.doi.org/10.4061/2011/235130
Research Article

Suspected Spontaneous Reports of Birth Defects in the UK Associated with the Use of Carbimazole and Propylthiouracil in Pregnancy

1Department of Paediatrics, Royal Devon and Exeter Hospital, Exeter, Devon EX25DW, UK
2Department of Endocrinology, Royal Devon and Exeter Hospital, Exeter, Devon EX25DW, UK
3Peninsula NIHR Clinical Research Facility, Level 2, Peninsula Medical School, University of Exeter, Barrack Road, Exeter, Devon EX25DW, UK

Received 19 April 2011; Revised 19 June 2011; Accepted 19 June 2011

Academic Editor: Kris Gustave Poppe

Copyright © 2011 Pamela Bowman and Bijay Vaidya. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. E. Krassas, K. Poppe, and D. Glinoer, “Thyroid function and human reproductive health,” Endocrine Reviews, vol. 31, no. 5, pp. 702–755, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  2. P. Barbero, R. Valdez, H. Rodríguez et al., “Choanal atresia associated with maternal hyperthyroidism treated with methimazole: a case-control study,” American Journal of Medical Genetics Part A, vol. 146, no. 18, pp. 2390–2395, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  3. M. Seoud, A. Nassar, I. Usta, M. Mansour, I. Salti, and K. Younes, “Gastrointestinal malformations in two infants born to women with hyperthyroidism untreated in the first trimester,” American Journal of Perinatology, vol. 20, no. 2, pp. 59–62, 2003. View at Google Scholar · View at Scopus
  4. N. Foulds, I. Walpole, F. Elmslie, and S. Mansour, “Carbimazole embryopathy: an emerging phenotype,” American Journal of Medical Genetics, vol. 132, no. 2, pp. 130–135, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  5. A. K. Myers and W. Reardon, “Choanal atresia—a recurrent feature of foetal carbimazole syndrome,” Clinical Otolaryngology, vol. 30, pp. 364–383, 2005. View at Google Scholar
  6. D. Wolf, N. Foulds, and H. Daya, “Antenatal carbimazole and choanal atresia: a new embryopathy,” Archives of Otolaryngology—Head and Neck Surgery, vol. 132, no. 9, pp. 1009–1011, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  7. L. Kannan, S. Mishra, R. Agarwal, V. Kartikeyan, N. Gupta, and M. Kabra, “Carbimazole embryopathy-bilateral choanal atresia and patent vitello-intestinal duct: a case report and review of literature,” Birth Defects Research Part A, vol. 82, no. 9, pp. 649–651, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  8. D. Koenig, A. Spreux, S. Hiéronimus et al., “Birth defects observed with maternal carbimazole treatment: six cases reported to Nice’s Pharmacovigilance Center,” Annales d'Endocrinologie, vol. 71, no. 6, pp. 535–542, 2010. View at Publisher · View at Google Scholar · View at PubMed
  9. P. Bowman, N. J. Osborne, R. Sturley, and B. Vaidya, “Carbimazole Embryopathy: implications for the choice of antithyroid drugs in pregnancy,” QJM. In press. View at Publisher · View at Google Scholar · View at PubMed
  10. O. Diav-Citrin and A. Ornoy, “Teratogen update: antithyroid drugs—methimazole, carbimazole, and propylthiouracil,” Teratology, vol. 65, no. 1, pp. 38–44, 2002. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  11. R. H. Mortimer, G. R. Cannell, R. S. Addison, L. P. Johnson, M. S. Roberts, and I. Bernus, “Methimazole and propylthiouracil equally cross the perfused human term placental lobule,” Journal of Clinical Endocrinology and Metabolism, vol. 82, no. 9, pp. 3099–3102, 1997. View at Publisher · View at Google Scholar · View at Scopus
  12. D. A. Wing, L. K. Millar, P. P. Koonings, M. N. Montoro, and J. H. Mestman, “A comparison of propylthiouracil versus methimazole in the treatment of hyperthyroidism in pregnancy,” American Journal of Obstetrics and Gynecology, vol. 170, no. 1, pp. 90–95, 1994. View at Google Scholar · View at Scopus
  13. M. Abalovich, N. Amino, L. A. Barbour et al., “Management of thyroid dysfunction during pregnancy and postpartum: an endocrine society clinical practice guideline,” Journal of Clinical Endocrinology and Metabolism, vol. 92, no. 8, pp. S1–S47, 2007. View at Publisher · View at Google Scholar
  14. Medicines and Healthcare Products Regulatory Agency / Commission on Human Medicines, United Kingdomhttp://www.mhra.gov.uk/.
  15. S. H. S. Pearce, “Spontaneous reporting of adverse reactions to carbimazole and propylthiouracil in the UK,” Clinical Endocrinology, vol. 61, no. 5, pp. 589–594, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  16. A. B. Emiliano, L. Governale, M. Parks, and D. S. Cooper, “Shifts in propylthiouracil and methimazole prescribing practices: antithyroid drug use in the United States from 1991 to 2008,” Journal of Clinical Endocrinology and Metabolism, vol. 95, no. 5, pp. 2227–2233, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  17. F. Azizi and A. Amouzegar, “Management of hyperthyroidism during pregnancy and lactation,” European Journal of Endocrinology, vol. 164, no. 6, pp. 871–876, 2011. View at Publisher · View at Google Scholar · View at PubMed
  18. H. Rosenfeld, A. Ornoy, S. Shechtman, and O. Diav-Citrin, “Pregnancy outcome, thyroid dysfunction and fetal goitre after in utero exposure to propylthiouracil: a controlled cohort study,” British Journal of Clinical Pharmacology, vol. 68, no. 4, pp. 609–617, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  19. F. A. Karlsson, O. Axelsson, and H. Melhus, “Severe embryopathy and exposure to methimazole in early preganancy,” Journal of Clinical Endocrinology and Metabolism, vol. 87, no. 2, pp. 947–948, 2002. View at Google Scholar
  20. M. Clementi, E. Di Gianantonio, M. Cassina et al., “Treatment of hyperthyroidism in pregnancy and birth defects,” Journal of Clinical Endocrinology and Metabolism, vol. 95, no. 11, pp. E337–E341, 2010. View at Publisher · View at Google Scholar · View at PubMed
  21. N. Momotani, K. Ito, N. Hamada, Y. Ban, Y. Nishikawa, and T. Mimura, “Maternal hyperthyroidism and congenital malformation in the offspring,” Clinical Endocrinology, vol. 20, no. 6, pp. 695–700, 1984. View at Google Scholar