The Central Effects of Thyroid Hormones on Appetite

Figure 1

Schematic diagram of central appetite regulation. T3 can access the hypothalamus and brainstem via the incomplete blood brain barrier. PVN: paraventricular nucleus; ARC: arcuate nucleus; VMN: ventromedial nucleus; BBB: blood-brain barrier; T3: triiodothyronine; POMC: Pro-opiomelanocortin; NPY: neuropeptide Y; AgRP: agouti-related protein; BDNF: brain-derived neurotrophic factor; HPT: hypothalamic-pituitary thyroid; SNS: sympathetic nervous system.