Pleiotropic Effects of Thyroid Hormones: Learning from Hypothyroidism

Figure 6

The effect of adenosine on urinary excretion of NO₂⁻/NO₃⁻ (NO₂⁻/NO₃⁻). Exogenous adenosine induces a decrease of the glomerular filtration rate (GFR) in normal (NL) kidneys and slightly increases the urinary excretions of nitrites. In contrast, in the hypothyroid (HTX) kidneys, despite the vasoconstriction, the urinary excretion of nitrates is within the normal range. When exogenous adenosine is administrated to HTX kidney, the glomerular filtration rate returns to normal values but is associated with a marked increase in the UNO₂⁻/NO₃⁻, suggesting that this effect is mediated by nitric oxide.

(a)

(b)