Journal of Thyroid Research / 2011 / Article / Tab 1

Review Article

Do Thyroid Disrupting Chemicals Influence Foetal Development during Pregnancy?

Table 1

Thyroid-disrupting properties of perchlorate in human studies on pregnant women, neonates, infants, adolescents, and adults and the effect of perchlorate on iodine contents in breast milk.

YearAuthorNSubjectsEffectReference

2005Tellez et al.185Early pregnant womenNo effect[38]
135Late pregnant womenNo effect
162NewbornsNo effect
2010Pearce et al.1641Pregnant womenNo effect[36]
2000Brechner et al.1542Newborns TSH[41]
2000Li et al.23000NewbornsNo effect[42]
2007Amitai et al.1156NewbornsNo effect[37]
2000Crump et al.9784Newborns TSH otherwise no effect[43]
162SchoolchildrenNo effect
2006Blount et al.350Iodine deficient women TT4 TSH[34]
697Iodine sufficient women TSH
MenNo effect
2000Lawrence et al.9Healthy volunteersNo effect[33]
thyroid radioiodine up-take
2002Greer et al.8Healthy volunteers thyroid radioiodine up-take[32]
2006Braverman et al.13Healthy volunteersNo effect[44]
1998Gibbs et al.119Occupationally exposedNo effect[45]
1999Lamm et al.58Occupationally exposedNo effect[46]
2005Braverman et al.29Occupationally exposed thyroid radioiodine up-take[31]
2005Kirk et al.36Lactating women Iodine in breast milk[39]
2007Pearce et al.57Lactating womenNo effect on iodine in breast milk[40]

N: number, TSH: thyrotropin, TT3: total tri-iodothyronine, TT4: total thyroxine, fT3: free Tri-iodothyronine, fT4: free thyroxine, and TBG: thyroid hormone-binding globulin.

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