Alterations along the Hypothalamic-Pituitary-Thyroid Axis of the Zebrafish (Danio rerio) after Exposure to Propylthiouracil

Table 3

Semiquantitative evaluation of alterations in the liver of zebrafish (Danio rerio) induced by PTU.

PTU (mg/L)	Control	2.5	10	25	50
Glycogen
Glycogen depletion	+	+	++	++	++
Mitochondria
Decrease in number			+	++	++
Rough endoplasmic reticulum
Fenestration			+	++	++
Reduction in amount			+	++	++

Data are given as means of observation in 10 individuals per exposure group: ⁺little developed; ⁺⁺moderately developed; ⁺⁺⁺strongly developed; ⁺⁺⁺⁺very strongly developed.