| | Thyroid tumor type | Analyzed samples | Methods | Tumor upregulated miRNAs | Tumor downregulated miRNAs | Reference |
| | PTC | 20 fresh PTC tissues versus 20 normal adjacent normal thyroid tissues | Global miRNA microarray, quantitative RT-PCR and Northern blots | miR-146b, miR-221, and miR-222 | — | He et al. [26] | | PTC | 30 fresh PTC tissues versus 10 normal thyroid tissues | Global miRNA microarray, quantitative RT-PCR, and Northern blots | miR-181b, miR-221, and miR-222 | — | Pallante et al. [27] | | PTC | 20 formalin-fixed paraffin-embedded PTC tissues versus 20 formalin-fixed paraffin-embedded multinodular goiter | Global miRNA microarray and quantitative RT-PCR | miR-21, miR-31, miR-34a, miR-172, miR-181a, miR-181b, miR-213, miR-221, miR-222, miR-223, and miR-224 | miR-19b-1,2, miR-30a-5p, miR-30c, miR-130b, miR-145sh, miR-218, miR-292-as, miR-300, and miR-345 | Tetzlaff et al. [28] | | PTC versus non-PTC | 84 formalin-fixed paraffin-embedded tissues and 40 ex vivo aspirate specimens of PTC and non-PTC tumors (follicular adenoma, follicular carcinoma hyperplastic nodules) | Quantitative RT-PCR | miR-146b, miR-221, and miR-222 | — | Chen et al. [29] | | PTC | 28 BRAF mutated PTC tissues versus 26 BRAF wild-type PTC tissues | Quantitative RT-PCR | No difference between mutated and nonmutated PTC | No difference between mutated and nonmutated PTC | Sheu et al. [31] | | PTC | 100 PTC tissues versus 16 paired normal thyroid control | Quantitative RT-PCR | miR-146b, miR-221, and miR-222 | — | Chou et al. [32] | | PTC | 2 PTC cell lines bearing a RET mutation versus normal thyroid cell lines | Global miRNA microarray | miR-34a, miR-96, miR-99a, miR-100, miR-125b, miR-128b, miR-130b, miR-139, miR-141, miR-142-3p, miR-146, miR-148, miR-185, miR-200a, miR-200b, miR-211, miR-213, miR-216, and let-7d | miR-15a, miR-34c, miR-107, miR-127, miR-135b, miR-145, miR-149, miR-154, miR-181a, miR-218, miR-299, miR-302b, miR-302c, miR-323, and miR-370 | Cahill et al. [40] | | FTC | 22 FTC samples versus 20 FA and 4 normal control thyroid tissues | Global miRNA microarrayand quantitative RT-PCR | miR-192, miR-197, miR-328, and miR-346 | — | Weber et al. [33] | | FTC PTC, other thyroid tumor variants | A 60-fresh-thyroid tumor and normal samples (23 PTCs, 9 FTCs, 8 FAs, 4 ATCs, 4 poorly differentiated carcinomas, 2 MTCs, 5 hyperplastic nodules, and 5 normal thyroid tissues) and 62 fine-needle aspiration samples | Quantitative RT-PCR | PTC: miR-31, miR-122a, miR-146b, miR-155, miR-187, miR-205, miR-221, miR-222, and miR-224
Conventional FA: miR-190, miR-205, miR-210, miR-224, miR-328, miR-339, and miR-342
Oncocytic FA: miR-31, miR-183, miR-203, miR-221, miR-224, and miR-339
Conventional FTC: miR-146b, miR-155, miR-187, miR-221, miR-222, and miR-224
Oncocytic FTC: miR-183, miR-187, miR-197, miR-221, miR-222, and miR-339
Poorly differentiated carcinomas: miR-129, miR-146b, miR-183, miR-187, miR-221, miR-222, and miR-339
ATC: miR-137, miR-155, miR-187, miR-205, miR-214, miR-221, miR-222, and miR-224
MTC: miR-9, miR-10a, miR-124a, miR-127, miR-129, miR-137, miR-154, miR-224, miR-323, and miR-370 | — | Nikiforova et al. [25] | | ATC | ATC tissues versus normal thyroid tissues | Global miRNA microarray, quantitative RT-PCR, Northern blots, and in situ hybridization | — | miR-26a, miR-30a-5p, miR-30d, and miR-125b | Visone et al. [34] | | ATC | 10 ATC and 5 FTC cell lines, 3 ATC and 8 PTC tissues versus normal thyroid samples | Quantitative RT-PCR | miR-21, miR-146b, miR-221, and miR-222 | miR-26a, miR-138, miR-219, and miR-345 | Mitomo et al. [38] | | ATC | ATC cell lines and ATC cancer lesions versus normal thyroid tissues | Global miRNA microarray, quantitative RT-PCR, and Northern blots | miR-17-3p, miR-17-5p, miR-18a, miR-19a, miR-19b, miR-20a, and miR-92-1 | — | Takakura et al. [37] | | ATC | ATC tissues versus PTC and FTC tissues | Global miRNA microarray and quantitative RT-PCR | — | miR-30 and miR-200 | Braun et al. [35] |
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