Review Article

Role of Estrogen in Thyroid Function and Growth Regulation

Table 2

Estrogen receptors (ER) α and β in human normal thyroid, and benign and malignant thyroid diseases, by immunohistochemistry (IHC).

StudyIsoformAll benignAll carcinomaBenign lesionsCarcinoma
AdenomaGoiterPapillaryFollicularMedullaryAnaplastic

Vaiman et al. [31]; 2010ERα0/340/1500/900/60/40/5
ERβ30/34126/15060/904/63/43/5
Winters et al. [32]; 2010ERα1/1
Vannucchi et al. [33]; 2010ERα12/38
Cho et al. [34]; 2007ERα10/11
ERβ8/11
Bléchet et al. [35]; 2007ERα0/28
ERβ26/28
Ceresini et al. [36]; 2006ERα0/170/17
ERβ17/1714/17

Data are shown as number of ER-positive samples/total number of samples.